Regioselectivity of Ln(OTf) 3 -catalysed alcoholysis of 2,3- and 3,4-epoxy alcohols was closely investigated to expand the scope of the transformations. The synthetic use was demonstrated by application to the construction of 4-propoxy-5-hydroxy-2,3-pentanedione (C4-propoxy-HPD), which is a potent synthetic mediator in AI-2 quorum sensing.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry