Living supramolecular polymerization realized through a biomimetic approach

Soichiro Ogi, Kazunori Sugiyasu, Swarup Manna, Sadaki Samitsu, Masayuki Takeuchi

Research output: Contribution to journalArticlepeer-review

474 Citations (Scopus)

Abstract

Various conventional reactions in polymer chemistry have been translated to the supramolecular domain, yet it has remained challenging to devise living supramolecular polymerization. To achieve this, self-organization occurring far from thermodynamic equilibrium - ubiquitously observed in nature - must take place. Prion infection is one example that can be observed in biological systems. Here, we present an 'artificial infection' process in which porphyrin-based monomers assemble into nanoparticles, and are then converted into nanofibres in the presence of an aliquot of the nanofibre, which acts as a 'pathogen'. We have investigated the assembly phenomenon using isodesmic and cooperative models and found that it occurs through a delicate interplay of these two aggregation pathways. Using this understanding of the mechanism taking place, we have designed a living supramolecular polymerization of the porphyrin-based monomers. Despite the fact that the polymerization is non-covalent, the reaction kinetics are analogous to that of conventional chain growth polymerization, and the supramolecular polymers were synthesized with controlled length and narrow polydispersity.

Original languageEnglish
Pages (from-to)188-195
Number of pages8
JournalNature Chemistry
Volume6
Issue number3
DOIs
Publication statusPublished - 2014 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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