Liver involvement in Tsutsugamushi disease

Atsushi Kanno, Miki Yamada, Kazuhiro Murakami, Wakio Torinuki

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Tsutsugamushi disease, one of the rickettsiosis, is known to be occasionally accompanied by elevation of hepatic enzyme levels. However, there are only a few reports on histopathological findings of the liver. We presented a case of Tsutsugamushi disease with liver involvement. A 51-year-old man suffered from eruptions and a high fever with a mild transaminasemia. He was diagnosed as Tsutsugamushi disease by detection of IgM class antibody against Rickettsia tsutsugamuski. Laparoscopic examination showed a dark-brown liver with diffuse whitish markings. Microscopic findings were consistent with the features of non-specific reactive hepatitis: sinusoidal small lymphocyte infiltrations, mild disarray of hepatocytes and aggregation of T lymphocytes and macrophages in the lobule.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalTohoku Journal of Experimental Medicine
Issue number3
Publication statusPublished - 1996 Jul


  • Liver disease
  • Rickettsiosis
  • Tsutsugamushi disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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