TY - JOUR
T1 - Liver injury suppressing compounds from avocado (Persea americana)
AU - Kawagishi, Hirokazu
AU - Fukumoto, Yuko
AU - Hatakeyama, Mina
AU - He, Puming
AU - Arimoto, Hirokazu
AU - Matsuzawa, Takaho
AU - Arimoto, Yasushi
AU - Suganuma, Hiroyuki
AU - Inakuma, Takahiro
AU - Sugiyama, Kimio
PY - 2001/9/26
Y1 - 2001/9/26
N2 - To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.
AB - To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.
KW - Avocado
KW - Fatty acid derivative
KW - Liver injury suppression
KW - Persea americana
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U2 - 10.1021/jf0015120
DO - 10.1021/jf0015120
M3 - Article
C2 - 11368579
AN - SCOPUS:17944375396
VL - 49
SP - 2215
EP - 2221
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
SN - 0021-8561
IS - 5
ER -