Liver injury suppressing compounds from avocado (Persea americana)

Hirokazu Kawagishi, Yuko Fukumoto, Mina Hatakeyama, Puming He, Hirokazu Arimoto, Takaho Matsuzawa, Yasushi Arimoto, Hiroyuki Suganuma, Takahiro Inakuma, Kimio Sugiyama

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.

Original languageEnglish
Pages (from-to)2215-2221
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume49
Issue number5
DOIs
Publication statusPublished - 2001 Sep 26
Externally publishedYes

Keywords

  • Avocado
  • Fatty acid derivative
  • Liver injury suppression
  • Persea americana

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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  • Cite this

    Kawagishi, H., Fukumoto, Y., Hatakeyama, M., He, P., Arimoto, H., Matsuzawa, T., Arimoto, Y., Suganuma, H., Inakuma, T., & Sugiyama, K. (2001). Liver injury suppressing compounds from avocado (Persea americana). Journal of Agricultural and Food Chemistry, 49(5), 2215-2221. https://doi.org/10.1021/jf0015120