Liver injury suppressing compounds from avocado (Persea americana)

Hirokazu Kawagishi; Yuko Fukumoto; Mina Hatakeyama; Puming He; Hirokazu Arimoto; Takaho Matsuzawa; Yasushi Arimoto; Hiroyuki Suganuma; Takahiro Inakuma; Kimio Sugiyama

doi:10.1021/jf0015120

Liver injury suppressing compounds from avocado (Persea americana)

Hirokazu Kawagishi, Yuko Fukumoto, Mina Hatakeyama, Puming He, Hirokazu Arimoto, Takaho Matsuzawa, Yasushi Arimoto, Hiroyuki Suganuma, Takahiro Inakuma, Kimio Sugiyama

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.

Original language	English
Pages (from-to)	2215-2221
Number of pages	7
Journal	Journal of Agricultural and Food Chemistry
Volume	49
Issue number	5
DOIs	https://doi.org/10.1021/jf0015120
Publication status	Published - 2001 Sep 26
Externally published	Yes

Keywords

Avocado
Fatty acid derivative
Liver injury suppression
Persea americana

ASJC Scopus subject areas

Chemistry(all)
Agricultural and Biological Sciences(all)

Access to Document

10.1021/jf0015120

Cite this

@article{40fdc524ff9948799fed08d6363f6223,

title = "Liver injury suppressing compounds from avocado (Persea americana)",

abstract = "To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.",

keywords = "Avocado, Fatty acid derivative, Liver injury suppression, Persea americana",

author = "Hirokazu Kawagishi and Yuko Fukumoto and Mina Hatakeyama and Puming He and Hirokazu Arimoto and Takaho Matsuzawa and Yasushi Arimoto and Hiroyuki Suganuma and Takahiro Inakuma and Kimio Sugiyama",

year = "2001",

month = sep,

day = "26",

doi = "10.1021/jf0015120",

language = "English",

volume = "49",

pages = "2215--2221",

journal = "Journal of Agricultural and Food Chemistry",

issn = "0021-8561",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - Liver injury suppressing compounds from avocado (Persea americana)

AU - Kawagishi, Hirokazu

AU - Fukumoto, Yuko

AU - Hatakeyama, Mina

AU - He, Puming

AU - Arimoto, Hirokazu

AU - Matsuzawa, Takaho

AU - Arimoto, Yasushi

AU - Suganuma, Hiroyuki

AU - Inakuma, Takahiro

AU - Sugiyama, Kimio

PY - 2001/9/26

Y1 - 2001/9/26

N2 - To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.

AB - To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.

KW - Avocado

KW - Fatty acid derivative

KW - Liver injury suppression

KW - Persea americana

UR - http://www.scopus.com/inward/record.url?scp=17944375396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17944375396&partnerID=8YFLogxK

U2 - 10.1021/jf0015120

DO - 10.1021/jf0015120

M3 - Article

C2 - 11368579

AN - SCOPUS:17944375396

VL - 49

SP - 2215

EP - 2221

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 5

ER -

Liver injury suppressing compounds from avocado (Persea americana)

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this