Liver injury suppressing compounds from avocado (Persea americana)

Hirokazu Kawagishi; Yuko Fukumoto; Mina Hatakeyama; Puming He; Hirokazu Arimoto; Takaho Matsuzawa; Yasushi Arimoto; Hiroyuki Suganuma; Takahiro Inakuma; Kimio Sugiyama

doi:10.1021/jf0015120

Liver injury suppressing compounds from avocado (Persea americana)

Hirokazu Kawagishi, Yuko Fukumoto, Mina Hatakeyama, Puming He, Hirokazu Arimoto, Takaho Matsuzawa, Yasushi Arimoto, Hiroyuki Suganuma, Takahiro Inakuma, Kimio Sugiyama

Research output: Contribution to journal › Article

58 Citations (Scopus)

Abstract

To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.

Original language	English
Pages (from-to)	2215-2221
Number of pages	7
Journal	Journal of Agricultural and Food Chemistry
Volume	49
Issue number	5
DOIs	https://doi.org/10.1021/jf0015120
Publication status	Published - 2001 Sep 26
Externally published	Yes

Keywords

Avocado
Fatty acid derivative
Liver injury suppression
Persea americana

ASJC Scopus subject areas

Chemistry(all)
Agricultural and Biological Sciences(all)

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10.1021/jf0015120

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Cite this

Kawagishi, H., Fukumoto, Y., Hatakeyama, M., He, P., Arimoto, H., Matsuzawa, T., Arimoto, Y., Suganuma, H., Inakuma, T., & Sugiyama, K. (2001). Liver injury suppressing compounds from avocado (Persea americana). Journal of Agricultural and Food Chemistry, 49(5), 2215-2221. https://doi.org/10.1021/jf0015120

Liver injury suppressing compounds from avocado (Persea americana). / Kawagishi, Hirokazu; Fukumoto, Yuko; Hatakeyama, Mina; He, Puming; Arimoto, Hirokazu; Matsuzawa, Takaho; Arimoto, Yasushi; Suganuma, Hiroyuki; Inakuma, Takahiro; Sugiyama, Kimio.

In: Journal of Agricultural and Food Chemistry, Vol. 49, No. 5, 26.09.2001, p. 2215-2221.

Research output: Contribution to journal › Article

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title = "Liver injury suppressing compounds from avocado (Persea americana)",

abstract = "To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.",

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author = "Hirokazu Kawagishi and Yuko Fukumoto and Mina Hatakeyama and Puming He and Hirokazu Arimoto and Takaho Matsuzawa and Yasushi Arimoto and Hiroyuki Suganuma and Takahiro Inakuma and Kimio Sugiyama",

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AU - Hatakeyama, Mina

AU - He, Puming

AU - Arimoto, Hirokazu

AU - Matsuzawa, Takaho

AU - Arimoto, Yasushi

AU - Suganuma, Hiroyuki

AU - Inakuma, Takahiro

AU - Sugiyama, Kimio

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N2 - To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.

AB - To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to rats with liver damage caused by D-galactosamine, a powerful liver toxin. As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity. Five active compounds were isolated and their structures determined. These were all fatty acid derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.

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