Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry

Kei Yamaura, Keiko Kuwata, Tomonori Tamura, Yoshiyuki Kioi, Yousuke Takaoka, Shigeki Kiyonaka, Itaru Hamachi

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

We demonstrate that ligand-directed tosyl (LDT) chemistry is applicable to off-target identification in live cells. Lapatinib (Lap)-based LDT reagents not only labeled a receptor tyrosine kinase, HER2, target protein, but also the protein disulfide isomerase (PDI) that should be an off-target protein for Lap.

Original languageEnglish
Pages (from-to)14097-14100
Number of pages4
JournalChemical Communications
Volume50
Issue number91
DOIs
Publication statusPublished - 2014 Oct 21
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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