Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture

A. Sugiyama, R. Arakaki, T. Ohnishi, N. Arakaki, Y. Daikuhara, H. Takada

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Lipoteichoic acids (LTA) from various gram-positive bacteria, including oral streptococci such as Streptococcus sanguis, enhanced the production of hepatocyte growth factor (HGF) (scatter factor) by human gingival fibroblasts in culture, whereas lipopolysaccharides (LPS) from various gram-negative bacteria did not. In contrast, LPS induced interleukin I activity in human gingival epithelial cells in culture, while LTA had little effect. LTA and recombinant human interleukin 1α enhanced synergistically the production of HGF/SF in human gingival fibroblast cultures. Recombinant human HGF, in turn, enhanced the proliferation of human gingival epithelial cells in culture.

Original languageEnglish
Pages (from-to)1426-1431
Number of pages6
JournalInfection and immunity
Volume64
Issue number4
DOIs
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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