Lipoprotein Glomerulopathy: Glomerular Lipoprotein Thrombi in a Patient With Hyperlipoproteinemia

Takao Saito, Hiroshi Sato, Ken ichi Kudo, Sin ichi Oikawa, Toshikatsu Shibata, Yoshihito Hara, Kaoru Yoshinaga, Hiroshi Sakaguchi

Research output: Contribution to journalArticlepeer-review

114 Citations (Scopus)

Abstract

An unusual nephropathy presumably induced by abnormal lipid metabolism is described in a 57-year-old woman who presented with proteinuria and edema. Histology at renal biopsy was characterized by marked dilatation of capillary lumina. Sudan staining and electron microscopy demonstrated lipid droplets occupying the capillary lumina. The patient had no particular clinical symptoms of lipidosis, but hyperlipoproteinemia similar to type III was suggested by lipid profiles. The nephropathy is thought to be an inherited disorder because proteinuria was detected in her sisters and similar renal histology and lipid profile were observed in one of her sisters. This is believed to be the first detailed report of glomerular lipoprotein thrombi.

Original languageEnglish
Pages (from-to)148-153
Number of pages6
JournalAmerican Journal of Kidney Diseases
Volume13
Issue number2
DOIs
Publication statusPublished - 1989

Keywords

  • Lipoprotein glomerulopathy
  • apolipoprotein E
  • glomerular lipoprotein thrombi
  • proteinuria
  • type III hyperlipoproteinemia

ASJC Scopus subject areas

  • Nephrology

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