Lipopolysaccharide induces manganese superoxide dismutase in the rat pancreas: Its role in cerulein pancreatitis

Reishi Abe, Tooru Shimosegawa, Shigeki Moriizumi, Yoshifumi Kikuchi, Kenji Kimura, Akihiko Satoh, Masaru Koizumi, Takayoshi Toyota

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Intraperitoneal injection of lipopolysaccharide (LPS) at a dose of 50 μg/kg increased the activity and the mRNA level of manganese superoxide dismutase (Mn-SOD) but did not change those of copper/zinc-SOD (Cu/Zn-SOD) in the rat pancreas. Both the formation of pancreatic edema and the elevation of serum amylase during caerulein pancreatitis were significantly relieved in the rats pretreated with LPS (50 μg/kg) compared with the rats without the pretreatment. These results support the view that superoxides play a key role in the pathogenesis of caerulein pancreatitis, and that Mn-SOD in the pancreas may work as a defense against the development of this disease.

Original languageEnglish
Pages (from-to)1216-1222
Number of pages7
JournalBiochemical and biophysical research communications
Volume217
Issue number3
DOIs
Publication statusPublished - 1995 Dec 26

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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