Lipopolysaccharide elicits expression of immune-related genes in the silkworm, Bombyx mori

H. Tanaka, A. Sagisaka, K. Fujita, Y. Kaneko, S. Imanishi, M. Yamakawa

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Lipopolysaccharide (LPS), a major cell wall component of Gram-negative bacteria, was found to be unable to activate immune-related genes in Drosophila melanogaster. In contrast, highly purified LPS elicited immune-related gene expression in the fat body of Bombyx mori. However, the level of activation by highly purified LPS was lower than crude LPS and peptidoglycan. Furthermore, synthetic lipid A also activated these genes, suggesting that B. mori possesses unknown signal pathways to activate immune-related genes by LPS. Up-regulation of antimicrobial peptide genes by highly purified LPS was not confirmed in the immune-responsive cell line, NIAS-Bm-aff3, suggesting that some factors necessary for signal transduction activated by LPS are deficient in this cell line.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalInsect Molecular Biology
Issue number1
Publication statusPublished - 2009 Feb 1
Externally publishedYes


  • Antimicrobial peptide gene
  • Bombyx mori
  • Insect immunity
  • Lipopolysaccharide

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Insect Science


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