Lipid peroxide-DNA adducts

Seon Hwa Lee, Ian A. Blair

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Increased production of reactive oxygen species during oxidative stress can initiate the formation of lipid hydroperoxides, which undergo homolytic decomposition to the α, β-unsaturated aldehydic bifunctional electrophiles, 4-oxo-2(E)- nonenal (ONE), 4-hydroxy-2(E)-nonenal (HNE), 4-hydroperoxy-2(E)-nonenal (HPNE), and malondialdehyde (MDA). Excessive lipid hydroperoxides can also be derived from the up-regulation of lipoxygenases (LOXs) and cyclooxygenases (COXs). Intracellular generation of the bifunctional electrophiles can then result in the formation of glutathione (GSH), protein, and DNA adducts. The analysis of lipid hydroperoxide-derived DNA adducts, such as ONE-derived heptanone-etheno DNA (HεDNA) adducts, can facilitate molecular epidemiology studies by providing insight into the amount of a genotoxin that has reached the DNA of the tissue under study. In addition, HεDNA adducts that are repaired and excreted in the urine can be used as specific biomarkers of lipid peroxidation-mediated DNA damage.

Original languageEnglish
Title of host publicationChemical Carcinogenesis
EditorsTrevor Penning
Pages227-244
Number of pages18
DOIs
Publication statusPublished - 2011 Dec 1

Publication series

NameCurrent Cancer Research
Volume6
ISSN (Print)0940-0745

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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