Lipid-lowering activity of phytostanols in rats

Michihiro Sugano, Fumiko Kamo, Ikuo Ikeda, Hidekazu Morioka

Research output: Contribution to journalArticlepeer-review

83 Citations (Scopus)


In the present study, the hypocholesterolemic activity of phytosterols and phytostanols was compared. Phytostanols were prepared by hydrogenating a phytosterol mixture from corn oil and were fed at different levels (0.1-1.0%) to male rats for 10 to 14 days with or without cholesterol (1.0%). In an appropriate combination with cholesterol, phytostanols showed significantly greater activity in lowering the plasma and possibly liver cholesterol levels in comparison with the corresponding phytosterols. The stanols further stimulated the fecal recovery of cholesterol. The rate of intestinal absorption of phytostanols appeared obviously lower than that of phytosterols and thus the deposition into plasma and liver lipids was almost negligible.

Original languageEnglish
Pages (from-to)301-309
Number of pages9
Issue number1-2
Publication statusPublished - 1976
Externally publishedYes


  • Cholesterol absorption
  • Hypolipidemic activity
  • Liver and plasma lipids
  • Phytostanols
  • Phytosterols

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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