Lipid compartmentalization in the endosome system

Françoise Hullin-Matsuda; Tomohiko Taguchi; Peter Greimel; Toshihide Kobayashi

doi:10.1016/j.semcdb.2014.04.010

Lipid compartmentalization in the endosome system

Françoise Hullin-Matsuda, Tomohiko Taguchi, Peter Greimel, Toshihide Kobayashi

Research output: Contribution to journal › Review article › peer-review

42 Citations (Scopus)

Abstract

Lipids play an essential role in the structure of the endosomal membranes as well as in their dynamic rearrangement during the transport of internalized cargoes along the endocytic pathway. In this review, we discuss the function of endosomal lipids mainly in mammalian cells, focusing on two well-known components of the lipid rafts, sphingomyelin and cholesterol, as well as on three anionic phospholipids, phosphatidylserine, polyphosphoinositides and the atypical phospholipid, bis(monoacylglycero)phosphate/lysobisphosphatidic acid. We detail the structure, metabolism, distribution and role of these lipids in the endosome system as well as their importance in pathological conditions where modification of the endosomal membrane flow can lead to various diseases such as lipid-storage diseases, myopathies and neuropathies.

Original language	English
Pages (from-to)	48-56
Number of pages	9
Journal	Seminars in Cell and Developmental Biology
Volume	31
DOIs	https://doi.org/10.1016/j.semcdb.2014.04.010
Publication status	Published - 2014 Jan 1
Externally published	Yes

Keywords

Bis(monoacylglycero)phosphate/lysobisphosphatidic acid
Cholesterol
Endocytosis
Phosphatidylserine
Polyphosphoinositides
Sphingomyelin

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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title = "Lipid compartmentalization in the endosome system",

abstract = "Lipids play an essential role in the structure of the endosomal membranes as well as in their dynamic rearrangement during the transport of internalized cargoes along the endocytic pathway. In this review, we discuss the function of endosomal lipids mainly in mammalian cells, focusing on two well-known components of the lipid rafts, sphingomyelin and cholesterol, as well as on three anionic phospholipids, phosphatidylserine, polyphosphoinositides and the atypical phospholipid, bis(monoacylglycero)phosphate/lysobisphosphatidic acid. We detail the structure, metabolism, distribution and role of these lipids in the endosome system as well as their importance in pathological conditions where modification of the endosomal membrane flow can lead to various diseases such as lipid-storage diseases, myopathies and neuropathies.",

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AU - Hullin-Matsuda, Françoise

AU - Taguchi, Tomohiko

AU - Greimel, Peter

AU - Kobayashi, Toshihide

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Y1 - 2014/1/1

N2 - Lipids play an essential role in the structure of the endosomal membranes as well as in their dynamic rearrangement during the transport of internalized cargoes along the endocytic pathway. In this review, we discuss the function of endosomal lipids mainly in mammalian cells, focusing on two well-known components of the lipid rafts, sphingomyelin and cholesterol, as well as on three anionic phospholipids, phosphatidylserine, polyphosphoinositides and the atypical phospholipid, bis(monoacylglycero)phosphate/lysobisphosphatidic acid. We detail the structure, metabolism, distribution and role of these lipids in the endosome system as well as their importance in pathological conditions where modification of the endosomal membrane flow can lead to various diseases such as lipid-storage diseases, myopathies and neuropathies.

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KW - Endocytosis

KW - Phosphatidylserine

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