Lipid compartmentalization in the endosome system

Françoise Hullin-Matsuda; Tomohiko Taguchi; Peter Greimel; Toshihide Kobayashi

doi:10.1016/j.semcdb.2014.04.010

Lipid compartmentalization in the endosome system

Françoise Hullin-Matsuda, Tomohiko Taguchi, Peter Greimel, Toshihide Kobayashi

Research output: Contribution to journal › Review article › peer-review

60 Citations (Scopus)

Abstract

Lipids play an essential role in the structure of the endosomal membranes as well as in their dynamic rearrangement during the transport of internalized cargoes along the endocytic pathway. In this review, we discuss the function of endosomal lipids mainly in mammalian cells, focusing on two well-known components of the lipid rafts, sphingomyelin and cholesterol, as well as on three anionic phospholipids, phosphatidylserine, polyphosphoinositides and the atypical phospholipid, bis(monoacylglycero)phosphate/lysobisphosphatidic acid. We detail the structure, metabolism, distribution and role of these lipids in the endosome system as well as their importance in pathological conditions where modification of the endosomal membrane flow can lead to various diseases such as lipid-storage diseases, myopathies and neuropathies.

Original language	English
Pages (from-to)	48-56
Number of pages	9
Journal	Seminars in Cell and Developmental Biology
Volume	31
DOIs	https://doi.org/10.1016/j.semcdb.2014.04.010
Publication status	Published - 2014 Jul
Externally published	Yes

Keywords

Bis(monoacylglycero)phosphate/lysobisphosphatidic acid
Cholesterol
Endocytosis
Phosphatidylserine
Polyphosphoinositides
Sphingomyelin

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.semcdb.2014.04.010

Cite this

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title = "Lipid compartmentalization in the endosome system",

abstract = "Lipids play an essential role in the structure of the endosomal membranes as well as in their dynamic rearrangement during the transport of internalized cargoes along the endocytic pathway. In this review, we discuss the function of endosomal lipids mainly in mammalian cells, focusing on two well-known components of the lipid rafts, sphingomyelin and cholesterol, as well as on three anionic phospholipids, phosphatidylserine, polyphosphoinositides and the atypical phospholipid, bis(monoacylglycero)phosphate/lysobisphosphatidic acid. We detail the structure, metabolism, distribution and role of these lipids in the endosome system as well as their importance in pathological conditions where modification of the endosomal membrane flow can lead to various diseases such as lipid-storage diseases, myopathies and neuropathies.",

keywords = "Bis(monoacylglycero)phosphate/lysobisphosphatidic acid, Cholesterol, Endocytosis, Phosphatidylserine, Polyphosphoinositides, Sphingomyelin",

author = "Fran{\c c}oise Hullin-Matsuda and Tomohiko Taguchi and Peter Greimel and Toshihide Kobayashi",

year = "2014",

month = jul,

doi = "10.1016/j.semcdb.2014.04.010",

language = "English",

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pages = "48--56",

journal = "Seminars in Cell Biology",

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T1 - Lipid compartmentalization in the endosome system

AU - Hullin-Matsuda, Françoise

AU - Taguchi, Tomohiko

AU - Greimel, Peter

AU - Kobayashi, Toshihide

PY - 2014/7

Y1 - 2014/7

N2 - Lipids play an essential role in the structure of the endosomal membranes as well as in their dynamic rearrangement during the transport of internalized cargoes along the endocytic pathway. In this review, we discuss the function of endosomal lipids mainly in mammalian cells, focusing on two well-known components of the lipid rafts, sphingomyelin and cholesterol, as well as on three anionic phospholipids, phosphatidylserine, polyphosphoinositides and the atypical phospholipid, bis(monoacylglycero)phosphate/lysobisphosphatidic acid. We detail the structure, metabolism, distribution and role of these lipids in the endosome system as well as their importance in pathological conditions where modification of the endosomal membrane flow can lead to various diseases such as lipid-storage diseases, myopathies and neuropathies.

AB - Lipids play an essential role in the structure of the endosomal membranes as well as in their dynamic rearrangement during the transport of internalized cargoes along the endocytic pathway. In this review, we discuss the function of endosomal lipids mainly in mammalian cells, focusing on two well-known components of the lipid rafts, sphingomyelin and cholesterol, as well as on three anionic phospholipids, phosphatidylserine, polyphosphoinositides and the atypical phospholipid, bis(monoacylglycero)phosphate/lysobisphosphatidic acid. We detail the structure, metabolism, distribution and role of these lipids in the endosome system as well as their importance in pathological conditions where modification of the endosomal membrane flow can lead to various diseases such as lipid-storage diseases, myopathies and neuropathies.

KW - Bis(monoacylglycero)phosphate/lysobisphosphatidic acid

KW - Cholesterol

KW - Endocytosis

KW - Phosphatidylserine

KW - Polyphosphoinositides

KW - Sphingomyelin

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DO - 10.1016/j.semcdb.2014.04.010

M3 - Review article

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JO - Seminars in Cell Biology

JF - Seminars in Cell Biology

SN - 1084-9521

ER -

Lipid compartmentalization in the endosome system

Abstract

Keywords

ASJC Scopus subject areas

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