Lipid compartmentalization in the endosome system

Françoise Hullin-Matsuda, Tomohiko Taguchi, Peter Greimel, Toshihide Kobayashi

Research output: Contribution to journalReview articlepeer-review

42 Citations (Scopus)

Abstract

Lipids play an essential role in the structure of the endosomal membranes as well as in their dynamic rearrangement during the transport of internalized cargoes along the endocytic pathway. In this review, we discuss the function of endosomal lipids mainly in mammalian cells, focusing on two well-known components of the lipid rafts, sphingomyelin and cholesterol, as well as on three anionic phospholipids, phosphatidylserine, polyphosphoinositides and the atypical phospholipid, bis(monoacylglycero)phosphate/lysobisphosphatidic acid. We detail the structure, metabolism, distribution and role of these lipids in the endosome system as well as their importance in pathological conditions where modification of the endosomal membrane flow can lead to various diseases such as lipid-storage diseases, myopathies and neuropathies.

Original languageEnglish
Pages (from-to)48-56
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume31
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Keywords

  • Bis(monoacylglycero)phosphate/lysobisphosphatidic acid
  • Cholesterol
  • Endocytosis
  • Phosphatidylserine
  • Polyphosphoinositides
  • Sphingomyelin

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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