Lipid biomarkers for the peroxisomal and lysosomal disorders: Their formation, metabolism and measurement

Ryuichi Mashima, Masamitsu Maekawa

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Lipid biomarkers play important roles in the diagnosis of and monitoring of treatment in peroxisomal disorders and lysosomal storage disorders. Today, a variety of lipids, including very long chain fatty acids, glycolipids, bile acids and the oxidation products of cholesterol, have been considered as biomarkers for these disorders. In this brief review, the authors summarized the recent advances regarding these lipid biomarkers in terms of their formation, metabolism and measurement in these disorders. An understanding of these biomarkers will offer a key to the development of novel diagnoses and help create more effective therapies in the future.

Original languageEnglish
Pages (from-to)83-95
Number of pages13
JournalBiomarkers in Medicine
Volume12
Issue number1
DOIs
Publication statusPublished - 2018 Jan

Keywords

  • 1-hexacosanoyl-2-hydroxy-sn-glycero-3-phosphocholine (LPC26:0)
  • bile acids
  • cholesterol oxidation products
  • globotriaosylceramide
  • liquid chromatography-tandem mass spectrometry
  • lysosomal storage disorders
  • peroxisomal disorders

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

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