Lipid bilayer vesicles with numbers of membrane-linking pores

Ken Ichirou Akashi, Hidetake Miyata

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report that phospholipid membranes spontaneously formed in aqueous medium giant unilamellar vesicles (GUVs) possessing many membranous wormhole-like structures (membrane-linking pores, MLPs). By phase contract microscopy and confocal.uorescence microscopy, the structures of the MLPs, consisting of lipid bilayer, were resolvable, and a variety of vesicular shapes having many MLPs (a high genus topology) were found. These vesicles were stable but easily deformed by micromanipulation with a microneedle. We also observed the size reduction of the MLPs with the increase in membrane tension, which was qualitatively consistent with a prediction from a simple dynamical model.

Original languageEnglish
Article number064801
Journaljournal of the physical society of japan
Volume79
Issue number6
DOIs
Publication statusPublished - 2010 Jun 1

Keywords

  • Giant vesicle
  • Liposome
  • Membrane linking pore
  • Phospholipid
  • Topology

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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