Linoleic acid-menthyl ester reduces the secretion of apolipoprotein B100 in HepG2 cells

Nao Inoue, Naomi Yamano, Kotaro Sakata, Keisuke Arao, Takashi Kobayashi, Toshihiro Nagao, Yuji Shimada, Koji Nagao, Teruyoshi Yanagita

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The effect of linoleic acid-menthyl ester (LAME) on lipid metabolism were assessed in HepG2 cells. It is well known that high level of apolipoprotein (apo) B100 in the serum is risk for atherosclerosis. Although linoleic acid (LA) treatment and LA plus L-mentol treatment increased apo B100 secretion, LAME treatment significantly decreased apo B100 secretion in HepG2 cells compared with control medium. The hypolipidemic effect of LAME was attributable to the suppression of triglyceride synthesis in HepG2 cells. It is also known that the risk of coronary heart disease is negatively related to the concentration of serum apo A-1. In the present study, LAME treatment increased apo A-1 secretion as compared with LA treatment in HepG2 cells. These results suggest that mentyl-esterification of fatty acids may be beneficial in anti-atherogenic dietary therapy.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalJournal of oleo science
Issue number4
Publication statusPublished - 2009
Externally publishedYes


  • Apolipoprotein A-1
  • Apolipoprotein B100
  • HepG2 cells
  • Linoleic acid-menthyl ester

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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