Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders

Yuta Takahashi, Zhiqian Yu, Mai Sakai, Hiroaki Tomita

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

A wide variety of studies have identified microglial activation in psychiatric disorders, such as schizophrenia, bipolar disorder, and major depressive disorder. Relatively fewer, but robust, studies have detected activation of peripheral monocytic cells in psychiatric disorders. Considering the origin of microglia, as well as neuropsychoimmune interactions in the context of the pathophysiology of psychiatric disorders, it is reasonable to speculate that microglia interact with peripheral monocytic cells in relevance with the pathogenesis of psychiatric disorders; however, these interactions have drawn little attention. In this review, we summarize findings relevant to activation of microglia and monocytic cells in psychiatric disorders, discuss the potential association between these cell types and disease pathogenesis, and propose perspectives for future research on these processes.

Original languageEnglish
Article number144
JournalFrontiers in Cellular Neuroscience
Volume10
Issue numberJUN
DOIs
Publication statusPublished - 2016 Jun 3

Keywords

  • Bipolar disorder
  • Blood-brain barrier
  • Mental disorder
  • Microglia
  • Monocyte
  • Peripheral biomarker
  • Psychoimmunology
  • Schizophrenia

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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