TY - JOUR
T1 - Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders
AU - Takahashi, Yuta
AU - Yu, Zhiqian
AU - Sakai, Mai
AU - Tomita, Hiroaki
N1 - Publisher Copyright:
© 2016 Takahashi, Yu, Sakai and Tomita.
PY - 2016/6/3
Y1 - 2016/6/3
N2 - A wide variety of studies have identified microglial activation in psychiatric disorders, such as schizophrenia, bipolar disorder, and major depressive disorder. Relatively fewer, but robust, studies have detected activation of peripheral monocytic cells in psychiatric disorders. Considering the origin of microglia, as well as neuropsychoimmune interactions in the context of the pathophysiology of psychiatric disorders, it is reasonable to speculate that microglia interact with peripheral monocytic cells in relevance with the pathogenesis of psychiatric disorders; however, these interactions have drawn little attention. In this review, we summarize findings relevant to activation of microglia and monocytic cells in psychiatric disorders, discuss the potential association between these cell types and disease pathogenesis, and propose perspectives for future research on these processes.
AB - A wide variety of studies have identified microglial activation in psychiatric disorders, such as schizophrenia, bipolar disorder, and major depressive disorder. Relatively fewer, but robust, studies have detected activation of peripheral monocytic cells in psychiatric disorders. Considering the origin of microglia, as well as neuropsychoimmune interactions in the context of the pathophysiology of psychiatric disorders, it is reasonable to speculate that microglia interact with peripheral monocytic cells in relevance with the pathogenesis of psychiatric disorders; however, these interactions have drawn little attention. In this review, we summarize findings relevant to activation of microglia and monocytic cells in psychiatric disorders, discuss the potential association between these cell types and disease pathogenesis, and propose perspectives for future research on these processes.
KW - Bipolar disorder
KW - Blood-brain barrier
KW - Mental disorder
KW - Microglia
KW - Monocyte
KW - Peripheral biomarker
KW - Psychoimmunology
KW - Schizophrenia
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U2 - 10.3389/fncel.2016.00144
DO - 10.3389/fncel.2016.00144
M3 - Review article
AN - SCOPUS:84975143391
VL - 10
JO - Frontiers in Cellular Neuroscience
JF - Frontiers in Cellular Neuroscience
SN - 1662-5102
IS - JUN
M1 - 144
ER -