Linearized Method: A New Approach for Kinetic Analysis of Central Dopamine D2 Receptor Specific Binding

Hiroshi Watabe; Jun Hatazawa; Kiichi Ishiwata; Tatsuo Ido; Toshihiro Takahashi; Kentaro Hatano; Takashi Nakamura

doi:10.1109/42.476110

Linearized Method: A New Approach for Kinetic Analysis of Central Dopamine D2 Receptor Specific Binding

Hiroshi Watabe, Jun Hatazawa, Kiichi Ishiwata, Tatsuo Ido, Toshihiro Takahashi, Kentaro Hatano, Takashi Nakamura

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We proposed a new method (‘Linearized method’) to analyze neuroleptic ligand-receptor specific binding in a human brain using positron emission tomography (PET). We derived the linear equation to solve four rate constants, k3, k4, k5, k6 from PET data. This method does not demand radioactivity curve in plasma as an input function to brain, and can do fast calculations in order to determine rate constants. We also tested Nonlinearized method including nonlinear equations which is conventional analysis using plasma radioactivity corrected for ligand metabolites as an input function. We applied these methods to evaluate dopamine D2 receptor specific binding of [11C] YM-09151-2. The value of Bmax/Kd = k3/k4 obtained by Linearized method was 5.72 ± 3.1 which was consistent with the value of 5.78 ± 3.4 obtained by Nonlinearized method.

Original language	English
Pages (from-to)	688-696
Number of pages	9
Journal	IEEE Transactions on Medical Imaging
Volume	14
Issue number	4
DOIs	https://doi.org/10.1109/42.476110
Publication status	Published - 1995 Dec
Externally published	Yes

ASJC Scopus subject areas

Software
Radiological and Ultrasound Technology
Computer Science Applications
Electrical and Electronic Engineering

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Cite this

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title = "Linearized Method: A New Approach for Kinetic Analysis of Central Dopamine D2 Receptor Specific Binding",

abstract = "We proposed a new method ({\textquoteleft}Linearized method{\textquoteright}) to analyze neuroleptic ligand-receptor specific binding in a human brain using positron emission tomography (PET). We derived the linear equation to solve four rate constants, k3, k4, k5, k6 from PET data. This method does not demand radioactivity curve in plasma as an input function to brain, and can do fast calculations in order to determine rate constants. We also tested Nonlinearized method including nonlinear equations which is conventional analysis using plasma radioactivity corrected for ligand metabolites as an input function. We applied these methods to evaluate dopamine D2 receptor specific binding of [11C] YM-09151-2. The value of Bmax/Kd = k3/k4 obtained by Linearized method was 5.72 ± 3.1 which was consistent with the value of 5.78 ± 3.4 obtained by Nonlinearized method.",

author = "Hiroshi Watabe and Jun Hatazawa and Kiichi Ishiwata and Tatsuo Ido and Toshihiro Takahashi and Kentaro Hatano and Takashi Nakamura",

year = "1995",

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journal = "IEEE Transactions on Medical Imaging",

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T2 - A New Approach for Kinetic Analysis of Central Dopamine D2 Receptor Specific Binding

AU - Watabe, Hiroshi

AU - Hatazawa, Jun

AU - Ishiwata, Kiichi

AU - Ido, Tatsuo

AU - Takahashi, Toshihiro

AU - Hatano, Kentaro

AU - Nakamura, Takashi

PY - 1995/12

Y1 - 1995/12

N2 - We proposed a new method (‘Linearized method’) to analyze neuroleptic ligand-receptor specific binding in a human brain using positron emission tomography (PET). We derived the linear equation to solve four rate constants, k3, k4, k5, k6 from PET data. This method does not demand radioactivity curve in plasma as an input function to brain, and can do fast calculations in order to determine rate constants. We also tested Nonlinearized method including nonlinear equations which is conventional analysis using plasma radioactivity corrected for ligand metabolites as an input function. We applied these methods to evaluate dopamine D2 receptor specific binding of [11C] YM-09151-2. The value of Bmax/Kd = k3/k4 obtained by Linearized method was 5.72 ± 3.1 which was consistent with the value of 5.78 ± 3.4 obtained by Nonlinearized method.

AB - We proposed a new method (‘Linearized method’) to analyze neuroleptic ligand-receptor specific binding in a human brain using positron emission tomography (PET). We derived the linear equation to solve four rate constants, k3, k4, k5, k6 from PET data. This method does not demand radioactivity curve in plasma as an input function to brain, and can do fast calculations in order to determine rate constants. We also tested Nonlinearized method including nonlinear equations which is conventional analysis using plasma radioactivity corrected for ligand metabolites as an input function. We applied these methods to evaluate dopamine D2 receptor specific binding of [11C] YM-09151-2. The value of Bmax/Kd = k3/k4 obtained by Linearized method was 5.72 ± 3.1 which was consistent with the value of 5.78 ± 3.4 obtained by Nonlinearized method.

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Linearized Method: A New Approach for Kinetic Analysis of Central Dopamine D2 Receptor Specific Binding

Abstract

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