Linearized Method: A New Approach for Kinetic Analysis of Central Dopamine D2 Receptor Specific Binding

Hiroshi Watabe, Jun Hatazawa, Kiichi Ishiwata, Tatsuo Ido, Toshihiro Takahashi, Kentaro Hatano, Takashi Nakamura

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We proposed a new method (‘Linearized method’) to analyze neuroleptic ligand-receptor specific binding in a human brain using positron emission tomography (PET). We derived the linear equation to solve four rate constants, k3, k4, k5, k6 from PET data. This method does not demand radioactivity curve in plasma as an input function to brain, and can do fast calculations in order to determine rate constants. We also tested Nonlinearized method including nonlinear equations which is conventional analysis using plasma radioactivity corrected for ligand metabolites as an input function. We applied these methods to evaluate dopamine D2 receptor specific binding of [11C] YM-09151-2. The value of Bmax/Kd = k3/k4 obtained by Linearized method was 5.72 ± 3.1 which was consistent with the value of 5.78 ± 3.4 obtained by Nonlinearized method.

Original languageEnglish
Pages (from-to)688-696
Number of pages9
JournalIEEE Transactions on Medical Imaging
Volume14
Issue number4
DOIs
Publication statusPublished - 1995 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering

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