Light-dependent development of asymmetry in the ipsilateral and contralateral thalamofugal visual projections of the chick

Mamiko Koshiba, Shun Nakamura, Chao Deng, Lesley J. Rogers

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Light-exposure of the chick embryo induces development of asymmetry in the thalamofugal visual projections to the Wulst regions of the forebrain since the embryo is turned so that it occludes its left and not its right eye. This asymmetry can be reversed by occluding the embryo's right eye and exposing its left eye to light. Here we show that three sub-regions of the thalamus (two in the dorsolateral anterior thalami (DLA) and one more caudal) have differing asymmetries of contralateral and/or ipsilateral projections. Hence the effect of asymmetrical light stimulation is regionally specific within the thalamus. Lateralised light stimulation appears to promote the development of ipsilateral projections from DLA pars dorsolateralis pars anterioris and contralateral projections from the caudal regions (the nucleus superficialis parvocellularis especially) but it may suppress the development of contralateral projections from the nucleus dorsolateralis anterior thalami pars lateralis rostralis. We also show that the light stimulation causes lateralised expression of c-fos and receptors for neurotransmitters.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalNeuroscience Letters
Volume336
Issue number2
DOIs
Publication statusPublished - 2003 Jan 16
Externally publishedYes

Keywords

  • c-fos
  • Laterality
  • Light
  • Nicotinic acetylcholine receptor
  • Thalamofugal
  • Visual Wulst

ASJC Scopus subject areas

  • Neuroscience(all)

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