TY - JOUR
T1 - Light activates the adrenal gland
T2 - Timing of gene expression and glucocorticoid release
AU - Ishida, Atsushi
AU - Mutoh, Tatsushi
AU - Ueyama, Tomoko
AU - Bando, Hideki
AU - Masubuchi, Satoru
AU - Nakahara, Daiichiro
AU - Tsujimoto, Gozoh
AU - Okamura, Hitoshi
N1 - Funding Information:
The authors wish to thank M. Kobayashi for making apparatus for photon-counting camera; S. Yamaguchi for the generation of Per1-luc animals; and R. Silver, K. Mishima, and S. Shibata for critical reading of the manuscript and inspiring discussion. We also give thanks to M. Nakamura for expert skill for the brain microdialysis technique; T. Todo for donating Cry1 −/− Cry2 −/− mice; and N. Kataoka, K. Katayose, T. Nishio, and D. Iwasawa for assistance. This work was supported by the Scientific Grants from the Ministry of Health, Welfare, and Labor, The Special Coordination Funds and the Scientific Grants of the 21st Century COE Program from Ministry of Education, Culture, Sports, Science, and Technology of Japan, SRF, and Hyogo Science and Technology Association.
PY - 2005/11
Y1 - 2005/11
N2 - Light is a powerful synchronizer of the circadian rhythms, and bright light therapy is known to improve metabolic and hormonal status of circadian rhythm sleep disorders, although its mechanism is poorly understood. In the present study, we revealed that light induces gene expression in the adrenal gland via the suprachiasmatic nucleus (SCN)-sympathetic nervous system. Moreover, this gene expression accompanies the surge of plasma and brain corticosterone levels without accompanying activation of the hypothalamo-adenohypophysial axis. The abolishment after SCN lesioning, and the day-night difference of light-induced adrenal gene expression and corticosterone release, clearly indicate that this phenomenon is closely linked to the circadian clock. The magnitude of corticostereone response is dose dependently correlated with the light intensity. The light-induced clock-dependent secretion of glucocorticoids adjusts cellular metabolisms to the new light-on environment.
AB - Light is a powerful synchronizer of the circadian rhythms, and bright light therapy is known to improve metabolic and hormonal status of circadian rhythm sleep disorders, although its mechanism is poorly understood. In the present study, we revealed that light induces gene expression in the adrenal gland via the suprachiasmatic nucleus (SCN)-sympathetic nervous system. Moreover, this gene expression accompanies the surge of plasma and brain corticosterone levels without accompanying activation of the hypothalamo-adenohypophysial axis. The abolishment after SCN lesioning, and the day-night difference of light-induced adrenal gene expression and corticosterone release, clearly indicate that this phenomenon is closely linked to the circadian clock. The magnitude of corticostereone response is dose dependently correlated with the light intensity. The light-induced clock-dependent secretion of glucocorticoids adjusts cellular metabolisms to the new light-on environment.
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U2 - 10.1016/j.cmet.2005.09.009
DO - 10.1016/j.cmet.2005.09.009
M3 - Article
C2 - 16271530
AN - SCOPUS:33645048181
VL - 2
SP - 297
EP - 307
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 5
ER -