Ligation errors in DNA computing

Yohei Aoi, Tatsuo Yoshinobu, Katsuyuki Tanizawa, Kozo Kinoshita, Hiroshi Iwasaki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

DNA computing is a novel method of computing proposed by Adleman (1994), in which the data is encoded in the sequences of oligonucleotides. Massively parallel reactions between oligonucleotides are expected to make it possible to solve huge problems. In this study, reliability of the ligation process employed in the DNA computing is tested by estimating the error rate at which wrong oligonucleotides are ligated. Ligation of wrong oligonucleotides would result in a wrong answer in the DNA computing. The dependence of the error rate on the number of mismatches between oligonucleotides and on the combination of bases is investigated.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalBioSystems
Volume52
Issue number1-3
DOIs
Publication statusPublished - 1999 Oct 1
Externally publishedYes

Keywords

  • DNA computing
  • Electrophoresis
  • Ligation
  • Oligonucleotide

ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics

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  • Cite this

    Aoi, Y., Yoshinobu, T., Tanizawa, K., Kinoshita, K., & Iwasaki, H. (1999). Ligation errors in DNA computing. BioSystems, 52(1-3), 181-187. https://doi.org/10.1016/S0303-2647(99)00045-3