Ligand-directed selective protein modification based on local single-electron-transfer catalysis

Shinichi Sato, Hiroyuki Nakamura

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

A photocatalyst ([Ru(bpy)3]2+) bound to a protein ligand was essential for the title method. Local single-electron transfer from the catalyst resulted in the formation of tyrosyl radicals. N′-Acetyl-N,N- dimethyl-1,4-phenylenediamine was used as the tyrosyl radical trapping agent and used in a radical addition to afford selective modification of the target protein.

Original languageEnglish
Pages (from-to)8681-8684
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number33
DOIs
Publication statusPublished - 2013 Aug 12
Externally publishedYes

Keywords

  • photocatalysts
  • protein modifications
  • radical reactions
  • single-electron transfer
  • tyrosine

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Ligand-directed selective protein modification based on local single-electron-transfer catalysis'. Together they form a unique fingerprint.

  • Cite this