Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea

Tomokazu Ohshiro, Yasufumi Emori, Kaoru Saigo

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Spatially and temporally regulated activity of Branchless/Breathless signaling is essential for trachea development in Drosophila. Early ubiquitous breathless (btl) expression is controlled by binding of Trachealess/Tango heterodimers to the btl minimum enhancer. Branchless/Breathless signaling includes a Sprouty-dependent negative feedback loop. We show that late btl expression is a target of Branchless/Breathless signaling and hence, Branchless/Breathless signaling contains a positive feedback loop, which may guarantee a continuous supply of fresh receptors to membranes of growing tracheal branch cells. Branchless/Breathless signaling activates MAP-kinase, which in turn, activates late btl expression and destabilizes Anterior-open, a repressor for late btl expression. Biochemical and genetic analysis indicated that the minimum btl enhancer includes binding sites of Anterior-open.

Original languageEnglish
Pages (from-to)3-11
Number of pages9
JournalMechanisms of Development
Volume114
Issue number1-2
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Anterior open
  • Branchless
  • Breathless
  • FGF receptor
  • MAP-kinase
  • Positive feedback

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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