TY - JOUR
T1 - Liberation of serotonin from rabbit blood platelets by bacterial cell walls and related compounds
AU - Harada, Kazuhiro
AU - Kotani, Shozo
AU - Takada, Haruhiko
AU - Tsujimoto, Masachika
AU - Hirachi, Yoshiyuki
AU - Kusumoto, Shoichi
AU - Shiba, Tetsuo
AU - Kawata, Shigeo
AU - Yokogawa, Kanae
AU - Nishimura, Hiroshi
AU - Kitaura, Toshiyuki
AU - Nakajima, Teruo
PY - 1982
Y1 - 1982
N2 - A study was made on the activity of various bacterial cell walls and peptidoglycans to liberate serotonin from rabbit blood platelets. All of the test cell walls or peptidoglycans prepared from 27 strains of 21 bacterial species were shown to cause a marked release of serotonin, regardless of differences in types of peptidoglycan and non-peptidoglycan moieties and in some biological properties. The assay made with the water-soluble 'digests' of Staphylococcus epidermidis cell wall peptidoglycans, which were prepared by use of appropriate enzymes, revealed that a polymer of peptidoglycan subunits (a disaccharide-stempeptide) was definitely active in the release of serotonin, but a structural unit monomer was inactive. Among a variety of synthetic muramylpeptides and their 6-O-acyl derivatives, only 6-O-(3-hydroxy-2-docosylhexacosanoyl)-N-acetylmuramyl-L-alanyl-D-isoglutamin yl-L-lysyl-D-alanine was found to hold a strong serotonin-liberating activity.
AB - A study was made on the activity of various bacterial cell walls and peptidoglycans to liberate serotonin from rabbit blood platelets. All of the test cell walls or peptidoglycans prepared from 27 strains of 21 bacterial species were shown to cause a marked release of serotonin, regardless of differences in types of peptidoglycan and non-peptidoglycan moieties and in some biological properties. The assay made with the water-soluble 'digests' of Staphylococcus epidermidis cell wall peptidoglycans, which were prepared by use of appropriate enzymes, revealed that a polymer of peptidoglycan subunits (a disaccharide-stempeptide) was definitely active in the release of serotonin, but a structural unit monomer was inactive. Among a variety of synthetic muramylpeptides and their 6-O-acyl derivatives, only 6-O-(3-hydroxy-2-docosylhexacosanoyl)-N-acetylmuramyl-L-alanyl-D-isoglutamin yl-L-lysyl-D-alanine was found to hold a strong serotonin-liberating activity.
UR - http://www.scopus.com/inward/record.url?scp=0019970769&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019970769&partnerID=8YFLogxK
U2 - 10.1128/iai.37.3.1181-1190.1982
DO - 10.1128/iai.37.3.1181-1190.1982
M3 - Article
C2 - 7129634
AN - SCOPUS:0019970769
VL - 37
SP - 1181
EP - 1190
JO - [No source information available]
JF - [No source information available]
IS - 3
ER -