Liberation of serotonin from rabbit blood platelets by bacterial cell walls and related compounds

Kazuhiro Harada, Shozo Kotani, Haruhiko Takada, Masachika Tsujimoto, Yoshiyuki Hirachi, Shoichi Kusumoto, Tetsuo Shiba, Shigeo Kawata, Kanae Yokogawa, Hiroshi Nishimura, Toshiyuki Kitaura, Teruo Nakajima

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


A study was made on the activity of various bacterial cell walls and peptidoglycans to liberate serotonin from rabbit blood platelets. All of the test cell walls or peptidoglycans prepared from 27 strains of 21 bacterial species were shown to cause a marked release of serotonin, regardless of differences in types of peptidoglycan and non-peptidoglycan moieties and in some biological properties. The assay made with the water-soluble 'digests' of Staphylococcus epidermidis cell wall peptidoglycans, which were prepared by use of appropriate enzymes, revealed that a polymer of peptidoglycan subunits (a disaccharide-stempeptide) was definitely active in the release of serotonin, but a structural unit monomer was inactive. Among a variety of synthetic muramylpeptides and their 6-O-acyl derivatives, only 6-O-(3-hydroxy-2-docosylhexacosanoyl)-N-acetylmuramyl-L-alanyl-D-isoglutamin yl-L-lysyl-D-alanine was found to hold a strong serotonin-liberating activity.

Original languageEnglish
Pages (from-to)1181-1190
Number of pages10
JournalUnknown Journal
Issue number3
Publication statusPublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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