LGR4 is required for the cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis

Yasuaki Mohri, Kazunori Oyama, Mizuki Sone, Atsushi Akamatsu, Katsuhiko Nishimori

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In mice, homozygous Lgr4 inactivation results in hypoplastic kidneys. To understand better the role of LGR4 in kidney development, we performed an analysis of kidneys in Lgr4-/- embryos. We stained Lgr4-/- kidneys with anti-WT1 and anti-Cleaved Caspase3 antibodies at E16.5, and observed that the structures of the cap mesenchyme were disrupted and that apoptosis increased. In addition, the expression of PAX2, an anti-apoptotic factor in kidney development, was also significantly decreased at E16.5. We found that the LGR4 defect caused an increase in apoptosis in the peripheral mesenchyme during kidney development.

Original languageEnglish
Pages (from-to)888-891
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number5
DOIs
Publication statusPublished - 2012

Keywords

  • Apoptosis
  • Kidney morphogenesis
  • Knockout mice
  • LGR4

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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