Leydig cell tumor of the ovary associated with endometrial carcinoma and containing 17β-hydroxysteroid dehydrogenase

Ryo Ichinohasama, Shinichi Teshima, Kiyozo Kishi, Kiyoshi Mukai, Ryuichiro Tsunematsu, Hiroko Ishii-Ohba, Yukio Shimosato

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

A case of ovarian Leydig cell tumor associated with adenocarci-noma of the endometrium in a 66-year-old woman is described herein, the eighth such case published. Clinically, both masculinizing and feminizing symptoms were observed: an increase in facial hair growth, slight baldness, clitoromegaly, and postmenopausal genital bleeding. Three biopsies of the endometrium during a 5-month preoperativc period showed atypical hyperplasia. Surgically resected material contained a Leydig cell tumor of the left ovary and focal adenocarcinoma in atypical hyperplasia of the endometrium. Serum levels of androgens and estrogens measured by radioimmunoassay decreased after removal of the tumor. Immunohistochemical studies revealed that the Leydig cell tumor contained testosterone, estrogens, and 17β-hydroxysteroid dehydrogenase (HSD) in the cytoplasm. This is the first report of a Leydig cell tumor in which the localization of 17β-HSD was demonstrated immunohisto-chemically.

Original languageEnglish
Pages (from-to)64-71
Number of pages8
JournalInternational Journal of Gynecological Pathology
Volume8
Issue number1
DOIs
Publication statusPublished - 1989 Mar
Externally publishedYes

Keywords

  • 17β-hydroxysteroid dehydrogenase
  • Endometrial carcinoma
  • Estrogens
  • Leydig cell tumor of the ovary
  • Testosterone

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology

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