Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome

Shigehiko Imagawa; Yuji Yamaguchi; Masato Higuchi; Tomohiro Neichi; Yuichi Hasegawa; Harumi Y. Mukai; Norio Suzuki; Masayuki Yamamoto; Toshiro Nagasawa

doi:10.1182/blood.V98.4.1255

Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome

Shigehiko Imagawa, Yuji Yamaguchi, Masato Higuchi, Tomohiro Neichi, Yuichi Hasegawa, Harumi Y. Mukai, Norio Suzuki, Masayuki Yamamoto, Toshiro Nagasawa

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

Abstract

To better understand how humans adapt to hypoxia, the levels of hemoglobin (Hb), serum erythropoietin (Epo), and vascular endothelial growth factor (VEGF) were measured in 106 patients with severe obstructive sleep apnea-hypopnea syndrome. The results indicated that temporal hypoxic stimulation increases Hb. Furthermore, a minor increase in Epo and a substantial increase in VEGF were found. The induction in patients with severe sleep apnea was greater than that reported in other types of hypoxia.

Original language	English
Pages (from-to)	1255-1257
Number of pages	3
Journal	Blood
Volume	98
Issue number	4
DOIs	https://doi.org/10.1182/blood.V98.4.1255
Publication status	Published - 2001 Aug 15
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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abstract = "To better understand how humans adapt to hypoxia, the levels of hemoglobin (Hb), serum erythropoietin (Epo), and vascular endothelial growth factor (VEGF) were measured in 106 patients with severe obstructive sleep apnea-hypopnea syndrome. The results indicated that temporal hypoxic stimulation increases Hb. Furthermore, a minor increase in Epo and a substantial increase in VEGF were found. The induction in patients with severe sleep apnea was greater than that reported in other types of hypoxia.",

author = "Shigehiko Imagawa and Yuji Yamaguchi and Masato Higuchi and Tomohiro Neichi and Yuichi Hasegawa and Mukai, {Harumi Y.} and Norio Suzuki and Masayuki Yamamoto and Toshiro Nagasawa",

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doi = "10.1182/blood.V98.4.1255",

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T1 - Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome

AU - Imagawa, Shigehiko

AU - Yamaguchi, Yuji

AU - Higuchi, Masato

AU - Neichi, Tomohiro

AU - Hasegawa, Yuichi

AU - Mukai, Harumi Y.

AU - Suzuki, Norio

AU - Yamamoto, Masayuki

AU - Nagasawa, Toshiro

PY - 2001/8/15

Y1 - 2001/8/15

N2 - To better understand how humans adapt to hypoxia, the levels of hemoglobin (Hb), serum erythropoietin (Epo), and vascular endothelial growth factor (VEGF) were measured in 106 patients with severe obstructive sleep apnea-hypopnea syndrome. The results indicated that temporal hypoxic stimulation increases Hb. Furthermore, a minor increase in Epo and a substantial increase in VEGF were found. The induction in patients with severe sleep apnea was greater than that reported in other types of hypoxia.

AB - To better understand how humans adapt to hypoxia, the levels of hemoglobin (Hb), serum erythropoietin (Epo), and vascular endothelial growth factor (VEGF) were measured in 106 patients with severe obstructive sleep apnea-hypopnea syndrome. The results indicated that temporal hypoxic stimulation increases Hb. Furthermore, a minor increase in Epo and a substantial increase in VEGF were found. The induction in patients with severe sleep apnea was greater than that reported in other types of hypoxia.

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Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome

Abstract

ASJC Scopus subject areas

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