Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome

Shigehiko Imagawa, Yuji Yamaguchi, Masato Higuchi, Tomohiro Neichi, Yuichi Hasegawa, Harumi Y. Mukai, Norio Suzuki, Masayuki Yamamoto, Toshiro Nagasawa

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)

Abstract

To better understand how humans adapt to hypoxia, the levels of hemoglobin (Hb), serum erythropoietin (Epo), and vascular endothelial growth factor (VEGF) were measured in 106 patients with severe obstructive sleep apnea-hypopnea syndrome. The results indicated that temporal hypoxic stimulation increases Hb. Furthermore, a minor increase in Epo and a substantial increase in VEGF were found. The induction in patients with severe sleep apnea was greater than that reported in other types of hypoxia.

Original languageEnglish
Pages (from-to)1255-1257
Number of pages3
JournalBlood
Volume98
Issue number4
DOIs
Publication statusPublished - 2001 Aug 15

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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