Levels of Porphyromonas gingivalis fimbriae and inflammatory cytokines in gingival crevicular fluid from adult human subjects

Kimiharu Hirose, Emiko Isogai, Hiroko Miura, Itsuo Ueda

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

The Porphyromonas gingivalis fimbriae level was examined in the gingival crevicular fluid (GCF) from adult human subjects using an immunoblot assay with a monoclonal antibody. The cytokines, interleukin-1α (IL-1α), IL-1β, IL-6 and tumor necrosis factor-α (TNF-α) levels in the GCF were quantified by enzyme-linked immunosorbent assay (ELISA). The reactivity of the GCF samples with the monoclonal antibody against P. gingivalis fimbriae was related to the IL-1β, IL-6 and TNF-α levels. Moreover, the fimbriae content was associated with the gingival index (GI). In contrast, no significant correlation was seen between the fimbriae content and IL-1α level. These results suggest that there are possible associations between P. gingivalis fimbriae and IL-1β, IL-6 and TNF-α in the gingival crevicular fluid.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalMICROBIOLOGY and IMMUNOLOGY
Volume41
Issue number1
DOIs
Publication statusPublished - 1997 Jan 1

Keywords

  • Adult periodontitis
  • Fimbriae
  • Inflammatory cytokine
  • Porphyromonas gingivalis

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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