Levels of endogenous interleukin-1, interleukin-6, and tumor necrosis factor in congenic mice infected with Borrelia garinii

Hiroshi Isogai, Koichi Kimura, Shunji Hayashi, Toru Kubota, Nobuhiro Fujii, Takeshi Nishikawa, Satoshi Kotake, Emiko Isogai

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

This study describes the levels of interleukin-1 alpha (IL-1α, tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) in the sera and parenchymal organs of various congenic mouse strains infected with Borrelia garinii. A significant elevation of inflammatory cytokine levels was found in the organs of C3H/HeN (H-2(k)) and B10.BR (H-2(k)) mice but not in those of BALB/c mice (H-2(d)). Focally produced cytokines can contribute to antimicrobial defense against these organisms. High levels of IL-1α were observed in the sera of C3H/HeN, B10.BR and B10 (H-2(b)) mice infected with B. garinii and they were associated with the presence of spirochetes in the skin. Thus, susceptible mice demonstrated a stronger cytokine response than resistant mice. This study presents in vivo evidence that B. garinii infection affects the immunopathogenesis of Lyme disease.

Original languageEnglish
Pages (from-to)427-430
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume41
Issue number5
DOIs
Publication statusPublished - 1997

Keywords

  • Borrelia garinii
  • Congenic mice
  • Inflammatory cytokines
  • Lyme disease

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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