Leukocyte margination at arteriole shear rate

Naoki Takeishi, Yohsuke Imai, Keita Nakaaki, Takami Yamaguchi, Takuji Ishikawa

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26 Citations (Scopus)

Abstract

We numerically investigated margination of leukocytes at arteriole shear rate in straight circular channels with diameters ranging from 10 to 22 lm. Our results demonstrated that passing motion of RBCs effectively induces leukocyte margination not only in small channels but also in large channels. A longer time is needed for margination to occur in a larger channel, but once a leukocyte has marginated, passing motion of RBCs occurs continuously independent of the channel diameter, and leukocyte margination is sustained for a long duration. We also show that leukocytes rarely approach the wall surface to within a microvillus length at arteriole shear rate.

Original languageEnglish
Article numbere12037
JournalPhysiological Reports
Volume2
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Computational biomechanics
  • Leukocyte margination
  • Microcirculation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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  • Cite this

    Takeishi, N., Imai, Y., Nakaaki, K., Yamaguchi, T., & Ishikawa, T. (2014). Leukocyte margination at arteriole shear rate. Physiological Reports, 2(6), [e12037]. https://doi.org/10.14814/phy2.12037