Leukocyte cyclic 3',5' nucleotide phosphodiesterase activity in human bronchial asthma

S. Mue, T. Ise, S. Shibahara, M. Takahashi, Y. Ono

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Changes in cyclic 3',5' nucleotide phosphodiesterase activity of the peripheral blood leukocytes were investigated in patients with bronchial asthma. Leukocyte phosphodiesterase activity was significantly elevated during asthmatic attacks. Elevated activity was seen in most active asthmatics irrespective of the drug treatment. The ratio of the adenyl cyclase activity to the phosphodiesterase activity of the same leukocyte decreased to less than 1.0 during asthmatic attacks.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalAnnals of Allergy
Volume37
Issue number3
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Immunology and Allergy

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