Leukocyte cyclic 3',5' nucleotide phosphodiesterase activity in human bronchial asthma

S. Mue; T. Ise; Shigeki Shibahara; M. Takahashi; Y. Ono

Leukocyte cyclic 3',5' nucleotide phosphodiesterase activity in human bronchial asthma

S. Mue, T. Ise, Shigeki Shibahara, M. Takahashi, Y. Ono

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Changes in cyclic 3',5' nucleotide phosphodiesterase activity of the peripheral blood leukocytes were investigated in patients with bronchial asthma. Leukocyte phosphodiesterase activity was significantly elevated during asthmatic attacks. Elevated activity was seen in most active asthmatics irrespective of the drug treatment. The ratio of the adenyl cyclase activity to the phosphodiesterase activity of the same leukocyte decreased to less than 1.0 during asthmatic attacks.

Original language	English
Pages (from-to)	201-207
Number of pages	7
Journal	Annals of Allergy
Volume	37
Issue number	3
Publication status	Published - 1976 Dec 1

ASJC Scopus subject areas

Immunology and Allergy

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title = "Leukocyte cyclic 3',5' nucleotide phosphodiesterase activity in human bronchial asthma",

abstract = "Changes in cyclic 3',5' nucleotide phosphodiesterase activity of the peripheral blood leukocytes were investigated in patients with bronchial asthma. Leukocyte phosphodiesterase activity was significantly elevated during asthmatic attacks. Elevated activity was seen in most active asthmatics irrespective of the drug treatment. The ratio of the adenyl cyclase activity to the phosphodiesterase activity of the same leukocyte decreased to less than 1.0 during asthmatic attacks.",

author = "S. Mue and T. Ise and Shigeki Shibahara and M. Takahashi and Y. Ono",

year = "1976",

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T1 - Leukocyte cyclic 3',5' nucleotide phosphodiesterase activity in human bronchial asthma

AU - Mue, S.

AU - Ise, T.

AU - Shibahara, Shigeki

AU - Takahashi, M.

AU - Ono, Y.

PY - 1976/12/1

Y1 - 1976/12/1

N2 - Changes in cyclic 3',5' nucleotide phosphodiesterase activity of the peripheral blood leukocytes were investigated in patients with bronchial asthma. Leukocyte phosphodiesterase activity was significantly elevated during asthmatic attacks. Elevated activity was seen in most active asthmatics irrespective of the drug treatment. The ratio of the adenyl cyclase activity to the phosphodiesterase activity of the same leukocyte decreased to less than 1.0 during asthmatic attacks.

AB - Changes in cyclic 3',5' nucleotide phosphodiesterase activity of the peripheral blood leukocytes were investigated in patients with bronchial asthma. Leukocyte phosphodiesterase activity was significantly elevated during asthmatic attacks. Elevated activity was seen in most active asthmatics irrespective of the drug treatment. The ratio of the adenyl cyclase activity to the phosphodiesterase activity of the same leukocyte decreased to less than 1.0 during asthmatic attacks.

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AN - SCOPUS:0017124714

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JO - Annals of Allergy, Asthma and Immunology

JF - Annals of Allergy, Asthma and Immunology

SN - 1081-1206

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ER -