Abstract
In a 72-year-old man with watery diarrhoea and leukocytosis the proliferation of abnormal cells was studied in specimens obtained by endoscopic biopsy of the gastrointestinal tract. Flow cytometry of leukaemia cells revealed a monoclonal expansion of "double-negative" (CD4-, CD8-) cells bearing T-cell receptor (TCR) αβ products. Southern blotting confirmed monoclonal integration of HTLV-I. A novel T-cell subset of double-negative TCR αβ cells in the gastrointestinal tract in adult man may be a target for HTLV-I infection.
Original language | English |
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Pages (from-to) | 76-77 |
Number of pages | 2 |
Journal | The Lancet |
Volume | 337 |
Issue number | 8733 |
DOIs | |
Publication status | Published - 1991 Jan 12 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)