Leukaemia of novel gastrointestinal T-lymphocyte population infected with HTLV-I

T. Hattori; N. Asou; H. Suzushima; K. Takatsuki; K. Tanaka; K. Naito; H. Natori; K. Oizumi

doi:10.1016/0140-6736(91)90737-A

Leukaemia of novel gastrointestinal T-lymphocyte population infected with HTLV-I

T. Hattori, N. Asou, H. Suzushima, K. Takatsuki, K. Tanaka, K. Naito, H. Natori, K. Oizumi

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

In a 72-year-old man with watery diarrhoea and leukocytosis the proliferation of abnormal cells was studied in specimens obtained by endoscopic biopsy of the gastrointestinal tract. Flow cytometry of leukaemia cells revealed a monoclonal expansion of "double-negative" (CD4-, CD8-) cells bearing T-cell receptor (TCR) αβ products. Southern blotting confirmed monoclonal integration of HTLV-I. A novel T-cell subset of double-negative TCR αβ cells in the gastrointestinal tract in adult man may be a target for HTLV-I infection.

Original language	English
Pages (from-to)	76-77
Number of pages	2
Journal	The Lancet
Volume	337
Issue number	8733
DOIs	https://doi.org/10.1016/0140-6736(91)90737-A
Publication status	Published - 1991 Jan 12
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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abstract = "In a 72-year-old man with watery diarrhoea and leukocytosis the proliferation of abnormal cells was studied in specimens obtained by endoscopic biopsy of the gastrointestinal tract. Flow cytometry of leukaemia cells revealed a monoclonal expansion of {"}double-negative{"} (CD4-, CD8-) cells bearing T-cell receptor (TCR) αβ products. Southern blotting confirmed monoclonal integration of HTLV-I. A novel T-cell subset of double-negative TCR αβ cells in the gastrointestinal tract in adult man may be a target for HTLV-I infection.",

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AU - Hattori, T.

AU - Asou, N.

AU - Suzushima, H.

AU - Takatsuki, K.

AU - Tanaka, K.

AU - Naito, K.

AU - Natori, H.

AU - Oizumi, K.

PY - 1991/1/12

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AB - In a 72-year-old man with watery diarrhoea and leukocytosis the proliferation of abnormal cells was studied in specimens obtained by endoscopic biopsy of the gastrointestinal tract. Flow cytometry of leukaemia cells revealed a monoclonal expansion of "double-negative" (CD4-, CD8-) cells bearing T-cell receptor (TCR) αβ products. Southern blotting confirmed monoclonal integration of HTLV-I. A novel T-cell subset of double-negative TCR αβ cells in the gastrointestinal tract in adult man may be a target for HTLV-I infection.

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