Leukaemia of novel gastrointestinal T-lymphocyte population infected with HTLV-I

T. Hattori, N. Asou, H. Suzushima, K. Takatsuki, K. Tanaka, K. Naito, H. Natori, K. Oizumi

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


In a 72-year-old man with watery diarrhoea and leukocytosis the proliferation of abnormal cells was studied in specimens obtained by endoscopic biopsy of the gastrointestinal tract. Flow cytometry of leukaemia cells revealed a monoclonal expansion of "double-negative" (CD4-, CD8-) cells bearing T-cell receptor (TCR) αβ products. Southern blotting confirmed monoclonal integration of HTLV-I. A novel T-cell subset of double-negative TCR αβ cells in the gastrointestinal tract in adult man may be a target for HTLV-I infection.

Original languageEnglish
Pages (from-to)76-77
Number of pages2
JournalThe Lancet
Issue number8733
Publication statusPublished - 1991 Jan 12
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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