Leucomyosuppressin, a novel insect neuropeptide, inhibits evoked transmitter release at the mealworm neuromuscular junction

Daisuke Yamamoto, Sachiyo Ishikawa, G. Mark Holman, Ronald J. Nachman

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    The action of leucomyosuppressin (LMS: pGlu-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2) on the glutamate-mediated neuromuscular transmission in the mealworm, Tenebrio molitor, was studied by the microelectrode current-clamp and voltage-clamp techniques. Submicromolar concentrations of LMS reversibly attenuate evoked release of transmitter from the motor nerve terminals, as evidenced by a decrease in the quantum content estimated by the number of failures of extracellular EPSPs. LMS has no effect on the glutamate-induced depolarization. Possible intracellular mediators for the LMS action are discussed.

    Original languageEnglish
    Pages (from-to)137-142
    Number of pages6
    JournalNeuroscience Letters
    Volume95
    Issue number1-3
    DOIs
    Publication statusPublished - 1988 Dec 19

    Keywords

    • Glutamate synapse
    • Presynaptic modulation

    ASJC Scopus subject areas

    • Neuroscience(all)

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