Abstract
The action of leucomyosuppressin (LMS: pGlu-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2) on the glutamate-mediated neuromuscular transmission in the mealworm, Tenebrio molitor, was studied by the microelectrode current-clamp and voltage-clamp techniques. Submicromolar concentrations of LMS reversibly attenuate evoked release of transmitter from the motor nerve terminals, as evidenced by a decrease in the quantum content estimated by the number of failures of extracellular EPSPs. LMS has no effect on the glutamate-induced depolarization. Possible intracellular mediators for the LMS action are discussed.
Original language | English |
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Pages (from-to) | 137-142 |
Number of pages | 6 |
Journal | Neuroscience Letters |
Volume | 95 |
Issue number | 1-3 |
DOIs | |
Publication status | Published - 1988 Dec 19 |
Keywords
- Glutamate synapse
- Presynaptic modulation
ASJC Scopus subject areas
- Neuroscience(all)