Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water

Masaaki Nakayama, Shigeru Kabayama, Hiroyuki Terawaki, Keisuke Nakayama, Kiyoshi Kato, Toshinobu Sato, Sadayoshi Ito

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Electrolyzed water (EW) generated on the cathode side reportedly displays anti-oxidative properties, and application of EW to hemodialysis (HD) systems supposedly suppresses oxidative markers in patients on HD. However, most of the chemical properties and biological effects of such solutions remain unclear. This study aimed to examine those issues to clarify the scientific background for the clinical use of EW solution. Reverse osmosis water comprising EW from the cathode side (e-RO) was prepared and used to process a test HD solution (e-HD). Chemical and biological properties of these solutions were compared with controls. Redox properties were examined by chemiluminescence (CL) of the luminol-H2O2 system. Biological effects of e-RO on human polymorphonuclear leukocytes (PMNs) were tested with respect to the cellular protection against methylglyoxal, and with respect to the preservation of cellular function as to radical generation. Control HD solution presented the highest CL, followed by e-HD, control RO, suggesting a lower oxidative capacity for EW-based solutions. Increased levels of dissolved hydrogen were characteristic of e-RO and e-HD. Application of e-RO tended to be associated with less injury of PMNs by methylglyoxal, and with significantly higher levels of radical generation compared with the control. Compared with control HD, e-RO-based HD solution displays less-oxidative capacity in chemical terms, and may at least partly facilitate preservation of PMN viability. These results appear to offer a scientific basis for supporting the clinical challenge of applying this technology to HD treatment.

Original languageEnglish
Pages (from-to)322-327
Number of pages6
JournalHemodialysis International
Volume11
Issue number3
DOIs
Publication statusPublished - 2007 Jul

Keywords

  • Dissolved hydrogen
  • Electrolyzed water
  • Hemodialysis solution
  • Oxidative stress
  • Viability of polymorphonuclear leukocytes

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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    Nakayama, M., Kabayama, S., Terawaki, H., Nakayama, K., Kato, K., Sato, T., & Ito, S. (2007). Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water. Hemodialysis International, 11(3), 322-327. https://doi.org/10.1111/j.1542-4758.2007.00187.x