Leptomeningeal metastasis from gynecologic cancers diagnosed by brain MRI

Masafumi Toyoshima; Keita Tsuji; Shogo Shigeta; Hideki Tokunaga; Kiyoshi Ito; Yoh Watanabe; Kosuke Yoshinaga; Takeo Otsuki; Hitoshi Niikura; Nobuo Yaegashi

doi:10.1016/j.clinimag.2016.09.013

Leptomeningeal metastasis from gynecologic cancers diagnosed by brain MRI

Masafumi Toyoshima, Keita Tsuji, Shogo Shigeta, Hideki Tokunaga, Kiyoshi Ito, Yoh Watanabe, Kosuke Yoshinaga, Takeo Otsuki, Hitoshi Niikura, Nobuo Yaegashi

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Leptomeningeal metastasis (LM) is rarely observed in gynecologic cancers. As gadolinium-enhanced magnetic resonance imaging (Gd-MRI) is highly effective for diagnosing LM, the aim of this study is to describe the clinical behaviors and outcomes of LM patients who were diagnosed by Gd-MRI. After securing institutional review board approvals, we retrospectively reviewed patient records. Eight patients were found to have LM from gynecological malignancies. Primary tumors included three ovarian cancers, one tubal cancer, one peritoneal cancer, two endometrial cancers, and one cervical cancer. Gd-MRI of the brain and the spine is indicated as the high-priority inspection for the diagnosis of this devastating complication.

Original language	English
Pages (from-to)	42-47
Number of pages	6
Journal	Clinical Imaging
Volume	41
DOIs	https://doi.org/10.1016/j.clinimag.2016.09.013
Publication status	Published - 2017 Jan 1

Keywords

Carcinomatous meningitis
Cytology
Gynecologic cancers
Leptomeningeal metastasis
Magnetic resonance imaging

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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@article{3150f9ede6864af09e5d78feff6cfa0d,

title = "Leptomeningeal metastasis from gynecologic cancers diagnosed by brain MRI",

abstract = "Leptomeningeal metastasis (LM) is rarely observed in gynecologic cancers. As gadolinium-enhanced magnetic resonance imaging (Gd-MRI) is highly effective for diagnosing LM, the aim of this study is to describe the clinical behaviors and outcomes of LM patients who were diagnosed by Gd-MRI. After securing institutional review board approvals, we retrospectively reviewed patient records. Eight patients were found to have LM from gynecological malignancies. Primary tumors included three ovarian cancers, one tubal cancer, one peritoneal cancer, two endometrial cancers, and one cervical cancer. Gd-MRI of the brain and the spine is indicated as the high-priority inspection for the diagnosis of this devastating complication.",

keywords = "Carcinomatous meningitis, Cytology, Gynecologic cancers, Leptomeningeal metastasis, Magnetic resonance imaging",

author = "Masafumi Toyoshima and Keita Tsuji and Shogo Shigeta and Hideki Tokunaga and Kiyoshi Ito and Yoh Watanabe and Kosuke Yoshinaga and Takeo Otsuki and Hitoshi Niikura and Nobuo Yaegashi",

note = "Funding Information: This study was supported in part by Research Promotion and Practical Use for Women's Health, AMED, JSPS KAKENHI Grants ( 23791801 and 26462509 to M.T. and 24390375 and 26670710 to N.Y.) and a Health Labor Sciences Research Grant ( 201221019A to N.Y.).",

year = "2017",

month = jan,

day = "1",

doi = "10.1016/j.clinimag.2016.09.013",

language = "English",

volume = "41",

pages = "42--47",

journal = "Clinical Imaging",

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T1 - Leptomeningeal metastasis from gynecologic cancers diagnosed by brain MRI

AU - Toyoshima, Masafumi

AU - Tsuji, Keita

AU - Shigeta, Shogo

AU - Tokunaga, Hideki

AU - Ito, Kiyoshi

AU - Watanabe, Yoh

AU - Yoshinaga, Kosuke

AU - Otsuki, Takeo

AU - Niikura, Hitoshi

AU - Yaegashi, Nobuo

N1 - Funding Information: This study was supported in part by Research Promotion and Practical Use for Women's Health, AMED, JSPS KAKENHI Grants ( 23791801 and 26462509 to M.T. and 24390375 and 26670710 to N.Y.) and a Health Labor Sciences Research Grant ( 201221019A to N.Y.).

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Leptomeningeal metastasis (LM) is rarely observed in gynecologic cancers. As gadolinium-enhanced magnetic resonance imaging (Gd-MRI) is highly effective for diagnosing LM, the aim of this study is to describe the clinical behaviors and outcomes of LM patients who were diagnosed by Gd-MRI. After securing institutional review board approvals, we retrospectively reviewed patient records. Eight patients were found to have LM from gynecological malignancies. Primary tumors included three ovarian cancers, one tubal cancer, one peritoneal cancer, two endometrial cancers, and one cervical cancer. Gd-MRI of the brain and the spine is indicated as the high-priority inspection for the diagnosis of this devastating complication.

AB - Leptomeningeal metastasis (LM) is rarely observed in gynecologic cancers. As gadolinium-enhanced magnetic resonance imaging (Gd-MRI) is highly effective for diagnosing LM, the aim of this study is to describe the clinical behaviors and outcomes of LM patients who were diagnosed by Gd-MRI. After securing institutional review board approvals, we retrospectively reviewed patient records. Eight patients were found to have LM from gynecological malignancies. Primary tumors included three ovarian cancers, one tubal cancer, one peritoneal cancer, two endometrial cancers, and one cervical cancer. Gd-MRI of the brain and the spine is indicated as the high-priority inspection for the diagnosis of this devastating complication.

KW - Carcinomatous meningitis

KW - Cytology

KW - Gynecologic cancers

KW - Leptomeningeal metastasis

KW - Magnetic resonance imaging

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