Left ventricular T1 mapping during chemotherapy-radiation therapy: Serial assessment of participants with esophageal cancer

Hidenobu Takagi, Hideki Ota, Rei Umezawa, Tomoyoshi Kimura, Noriyuki Kadoya, Satoshi Higuchi, Wenyu Sun, Yujiro Nakajima, Masahide Saito, Yoshiaki Komori, Keiichi Jingu, Kei Takase

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Purpose: To assess changes in left ventricular function and tissue composition by using MRI after chemotherapy-radiation therapy in participants with esophageal cancer. Materials and Methods: Between January 2013 and April 2015, this prospective study enrolled 24 participants (42% women; mean age, 63 years; range, 49-73 years) scheduled for chemotherapy-radiation therapy. 3.0-T MRI examinations were performed before, at 0.5 year, and at 1.5 years after chemotherapy-radiation therapy. Myocardial native T1, postcontrast T1, and extracellular volume were measured in basal septum (as irradiated areas) and apical lateral wall (as nonirradiated areas). Left ventricular function, prevalence of late gadolinium enhancement, and T1 and extracellular volume values were compared over the follow-up period by using Friedman or Cochran Q tests, followed by Dunn test. Results: In 14 participants who were followed up for 1.5 years, native T1 and extracellular volume in the septum were elevated at 0.5 year compared with baseline (1183 msec 6 46 [standard deviation] vs 1257 msec ± 35; 26% ± 3 vs 32% ± 3; adjusted P <.01 for both), but not in the lateral wall. Left ventricular stroke volume index and late gadolinium enhancement changed at 1.5 years compared with baseline (41 mL/m2 6 11 vs 36 mL/m2 ± 9; P =.046; 7% [one of 14] vs 78% [11 of 14]; P <.01). Other measures of left ventricular function did not change during the follow-up period (P. 10 for all). Conclusion: Native T1 and extracellular volume could detect early changes in myocardium at 0.5 year after chemotherapy-radiation therapy, whereas left ventricular stroke volume index and late gadolinium enhancement showed abnormality at 1.5 years.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalRadiology
Volume289
Issue number2
DOIs
Publication statusPublished - 2018 Nov

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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