Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels as a Biomarker of Acute Intracerebral Hemorrhage

Takashi Inoue, Tomohisa Ishida, Tomoo Inoue, Atsushi Saito, Masayuki Ezura, Hiroshi Uenohara, Miki Fujimura, Kenichi Sato, Toshiki Endo, Shunsuke Omodaka, Hidenori Endo, Kuniyasu Niizuma, Teiji Tominaga

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background: Correct diagnosis of cerebral stroke type, hemorrhagic or ischemic, is essential in the early stage to establish the optimum treatment. The diagnosis is mainly determined based on imaging studies. Other more available diagnostic methods are desirable, such as blood sample examination. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is very important in vascular dysfunction induced by oxidized low-density lipoprotein, including cell apoptosis. The present study evaluated LOX-1 as a biomarker for cerebral stroke. Subjects and Methods: Patients with newly diagnosed stroke were prospectively enrolled between February and July 2014. LOX-1 serum values were measured twice, within 24 hours and 2 months after the onset. Results: A total of 16 patients were enrolled; 7 patients with intracerebral hemorrhage (ICH) and 9 patients with cerebral infarction. Median LOX-1 values of patients with ICH and infarction in the acute phase were 1825.8 and 593.9 pg/mL, respectively, significantly higher in patients with ICH than in patients with infarction (P <.0001). Conclusion: LOX-1 serum level has potential as a biomarker of ICH.

Original languageEnglish
Pages (from-to)490-494
Number of pages5
JournalJournal of Stroke and Cerebrovascular Diseases
Volume28
Issue number2
DOIs
Publication statusPublished - 2019 Feb

Keywords

  • Biomarker
  • Diagnosis
  • Diagnostic testing
  • Intracranial hemorrhage
  • intracerebral hemorrhage
  • lectin-like oxidized low-density lipoprotein receptor-1

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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