Lectin histochemistry in mucinous and serous ovarian neoplasms

Hironobu Sasano, Yuko Saito, Hiroshi Nagura, Ryuichi Kudo, Magaly Rojas, Steven G. Silverberg

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The lectin-binding properties of 44 cases of serous and mucinous ovarian cystadenoma, tumor of low malignant potential (LMP), and invasive carcinoma were examined histochemically. Wheat germ agglutinin (WGA), concanavalin A (con A), Ulex europaeus agglutinin I (UEA-I), peanut agglutinin (PNA), Ricinus communis agglutinin I (RCA-I), soybean agglutinin (SBA), and Robina pseudoaccacia (RPA) were employed. All the lectins examined were bound to neoplastic epithelial cells of benign and malignant tumors, but none bound exclusively to ovarian tumor cells. Different lectin-binding patterns between serous and mucinous neoplasms were observed, with the exception of RPA. UEA-I, con A, RPA, and PNA in serous neoplasms and UEA-I, RPA, and WGA in mucinous neoplasms demonstrated lectin-binding properties of LMP tumors intermediate between those of cystadenoma and invasive carcinoma. These findings indicate that serous and mucinous ovarian neoplasms contain different glycoconjugates, that malignant transformation of the neoplasms is associated with alteration of these glycoconjugates, and especially that LMP tumors have a different composition of cellular glycoconjugates from that of invasive ovarian carcinoma.

Original languageEnglish
Pages (from-to)252-259
Number of pages8
JournalInternational Journal of Gynecological Pathology
Volume10
Issue number3
DOIs
Publication statusPublished - 1991 Jul

Keywords

  • Histochemistry
  • Lectin
  • Neoplasms
  • Ovary

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology

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