Lectin and antibody bindings in pleomorphic adenoma of lacrimal gland

M. Ishikawa, K. Fujimori, T. Koseki

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Abstract

We performed immunohistochemical studies on pleomorphic adenoma of lacrimal gland in a 22-year-old male. We examined the binding sites of 7 antibodies and 8 lectins. The cell type of pleomorphic adenoma was divided into 3 groups: epithelial cell lining on the luminal surface of the duct, spindle-shaped cells of mesenchymal origin, and transformed cells of both types. Anti-EMA (epithelial membrane antigen) antibody and SBA (glycine max) were specifically bound to the epithelial cells. The mesenchymal component was labelled with anti-GFAP (glial fibrillary acidic protein) antibody and GS-2 (griffonia simplicifolia 2). The transformed cells showed cross reactivity for antikeratin and antivimentin antibodies and for GS-1 and PNA (arachis hypogaea). The findings suggest the usefulness of lectin cytochemistry to distinguish cell types in pleomorphic adenoma. It is presumed that GS-2 recognizes the tumor-associated antigen.

Original languageEnglish
Pages (from-to)821-824
Number of pages4
JournalJapanese Journal of Clinical Ophthalmology
Volume48
Issue number5
Publication statusPublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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