Lecithin: Cholesterol acyltransferase is insufficient to prevent oxidative modification of low-density lipoprotein

Youhei Murakami, Shin Kamiyama, Zakir H. Howlader, Tokuhisa Yamato, Michio Komai, Yuji Furukawa

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We tried to confirm the antioxidative capability of lecithin:cholesterol acyltransferase (LCAT) reported by Vohl et al. [Biochemistry (1999) 38, 5976-5981]. The enzyme solution protected LDL against oxidation. However, this protection was not due to LCAT enzyme, but to some unknown low-molecular-weight substance(s) in the solution; LCAT itself exerted little protective effect against LDL oxidation.

Original languageEnglish
Pages (from-to)17-19
Number of pages3
JournalJournal of biochemistry
Volume131
Issue number1
DOIs
Publication statusPublished - 2002 Jan 1

Keywords

  • Antioxidation
  • High-density lipoprotein
  • Lecithin:cholesterol acyltransferase
  • Low-density lipoprotein
  • Oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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