Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea

Jang Ja Hong, Kuk Hyun Shin, Soon Sung Lim, Jong Hwan Kwak, Ok Pyo Zee, Kenji Ishihara, Noriyasu Hirasawa, Toshio Seyama, Kazuo Ohuchi

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Effects of compounds isolated from medicinal plants in Korea on prostaglandin E2 (PGE2) production in rat peritoneal macrophages were examined, and mechanism of action of the active constituents was analyzed. The active constituents were as follows; tectorigenin and tectoridin isolated from the rhizomes of Belamcanda chinensis, platycodin D isolated from the roots of Platycodon grandiflorum, imperatorin isolated from the roots of Angelica dahurica, and hyperin isolated from the roots of Acanthopanax chiisanensis. These compounds inhibit the induction of cyclooxygenase-2 (COX-2), thus inhibiting PGE2 production. The chemically synthesized chalcone derivative, 2′-hydroxy-4′-methoxychalcone, also inhibits PGE2 production by suppressing COX-2 induction. In contrast, taiwanin C isolated from the roots of Acanthopanax chiisanensis inhibited PGE2 production by direct inhibition of COX-1 and COX-2.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalInflammation and Allergy - Drug Targets
Volume7
Issue number3
DOIs
Publication statusPublished - 2008 Sep 1

Keywords

  • 2'-hydroxy-4'- methoxychalcone
  • Cyclooxygenase-2
  • Hyperin
  • Imperatorin
  • Macrophage
  • Platycodin D
  • Prostaglin E
  • Taiwanin C
  • Tectorigenin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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