TY - JOUR
T1 - LDL-apheresis reduces P-selectin, CRP and fibrinogen - Possible important implications for improving atherosclerosis
AU - Kobayashi, Shuzo
AU - Oka, Machiko
AU - Moriya, Hidekazkeu
AU - Maesato, Kyoko
AU - Okamoto, Koji
AU - Ohtake, Takayasu
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Although it is known that LDL-apheresis improves coronary artery stenosis (CAS) as well as ischemic limbs seen in patients with peripheral arterial occlusive disease (PAOD), the underlying mechanisms remain still unknown. LDL-apheresis might exert its favorable action through anti-inflammatory effects. We studied whether or not serum or plasma levels of P-selectin, high sensitivity C-reactive protein (hsCRP), monocyte chemotractant protein-1 (MCP-1) or fibrinogen could be reduced in patients with PAOD before and after 10 sessions of LDL-apheresis. Sixteen patients (12 patients with hemodialysis, HD) with PAOD were enrolled in the present study. LDL-apheresis was carried out 10 times (treated plasma of 3000 mL) over 5 weeks. Serum levels of P-selectin were significantly reduced from 516 ± 153 to 290 ± 52 ng/mL before and after 10-sessions of LDL-apheresis, respectively (P < 0.05). Likewise, serum levels of hsCRP decreased from 9.118 ± 2.649 to 5.587 ± 2.445 mg/L (P < 0.01); and plasma fibrinogen levels statistically decreased from 196 ± 9.82 to 149 ± 7.97 mg/dL (P < 0.01), whereas serum levels of MCP-1 were not significantly changed. The favorable actions of LDL-apheresis might include anti-inflammatory effects, which could lead to an improvement of CAS and PAOD. Moreover, this intervention might be applicable for patients with atherosclerotic cardiovascular disorders, particularly in patients with HD.
AB - Although it is known that LDL-apheresis improves coronary artery stenosis (CAS) as well as ischemic limbs seen in patients with peripheral arterial occlusive disease (PAOD), the underlying mechanisms remain still unknown. LDL-apheresis might exert its favorable action through anti-inflammatory effects. We studied whether or not serum or plasma levels of P-selectin, high sensitivity C-reactive protein (hsCRP), monocyte chemotractant protein-1 (MCP-1) or fibrinogen could be reduced in patients with PAOD before and after 10 sessions of LDL-apheresis. Sixteen patients (12 patients with hemodialysis, HD) with PAOD were enrolled in the present study. LDL-apheresis was carried out 10 times (treated plasma of 3000 mL) over 5 weeks. Serum levels of P-selectin were significantly reduced from 516 ± 153 to 290 ± 52 ng/mL before and after 10-sessions of LDL-apheresis, respectively (P < 0.05). Likewise, serum levels of hsCRP decreased from 9.118 ± 2.649 to 5.587 ± 2.445 mg/L (P < 0.01); and plasma fibrinogen levels statistically decreased from 196 ± 9.82 to 149 ± 7.97 mg/dL (P < 0.01), whereas serum levels of MCP-1 were not significantly changed. The favorable actions of LDL-apheresis might include anti-inflammatory effects, which could lead to an improvement of CAS and PAOD. Moreover, this intervention might be applicable for patients with atherosclerotic cardiovascular disorders, particularly in patients with HD.
KW - C-reactive protein
KW - Coronary artery stenosis
KW - LDL-apheresis
KW - P-selectin
KW - Peripheral arterial occlusive disese (PAOD)
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U2 - 10.1111/j.1744-9987.2006.00332.x
DO - 10.1111/j.1744-9987.2006.00332.x
M3 - Article
C2 - 16817784
AN - SCOPUS:33745572748
VL - 10
SP - 219
EP - 223
JO - Therapeutic Apheresis and Dialysis
JF - Therapeutic Apheresis and Dialysis
SN - 1744-9979
IS - 3
ER -