LDL-apheresis reduces P-selectin, CRP and fibrinogen - Possible important implications for improving atherosclerosis

Shuzo Kobayashi, Machiko Oka, Hidekazkeu Moriya, Kyoko Maesato, Koji Okamoto, Takayasu Ohtake

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Although it is known that LDL-apheresis improves coronary artery stenosis (CAS) as well as ischemic limbs seen in patients with peripheral arterial occlusive disease (PAOD), the underlying mechanisms remain still unknown. LDL-apheresis might exert its favorable action through anti-inflammatory effects. We studied whether or not serum or plasma levels of P-selectin, high sensitivity C-reactive protein (hsCRP), monocyte chemotractant protein-1 (MCP-1) or fibrinogen could be reduced in patients with PAOD before and after 10 sessions of LDL-apheresis. Sixteen patients (12 patients with hemodialysis, HD) with PAOD were enrolled in the present study. LDL-apheresis was carried out 10 times (treated plasma of 3000 mL) over 5 weeks. Serum levels of P-selectin were significantly reduced from 516 ± 153 to 290 ± 52 ng/mL before and after 10-sessions of LDL-apheresis, respectively (P < 0.05). Likewise, serum levels of hsCRP decreased from 9.118 ± 2.649 to 5.587 ± 2.445 mg/L (P < 0.01); and plasma fibrinogen levels statistically decreased from 196 ± 9.82 to 149 ± 7.97 mg/dL (P < 0.01), whereas serum levels of MCP-1 were not significantly changed. The favorable actions of LDL-apheresis might include anti-inflammatory effects, which could lead to an improvement of CAS and PAOD. Moreover, this intervention might be applicable for patients with atherosclerotic cardiovascular disorders, particularly in patients with HD.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalTherapeutic Apheresis and Dialysis
Volume10
Issue number3
DOIs
Publication statusPublished - 2006 Jun 1
Externally publishedYes

Keywords

  • C-reactive protein
  • Coronary artery stenosis
  • LDL-apheresis
  • P-selectin
  • Peripheral arterial occlusive disese (PAOD)

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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