Layer-by-layer assembled thin films composed of carboxyl-terminated poly(amidoamine) dendrimer as a pH-sensitive nano-device

Shigeru Tomita, Katsuhiko Sato, Jun ichi Anzai

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)

Abstract

Dendrimer-containing multilayer thin films have successfully been prepared by a layer-by-layer deposition of carboxyl-terminated poly(amidoamine) dendrimer (PAMAM-COOH) and poly(methacrylic acid) (PMA) on a solid surface at pH 4.0, while the multilayer film did not form at pH 7.0. The PMA/PAMAM-COOH multilayer films prepared at pH 4.0 are decomposed at neutral pH due to electrostatic repulsion between negatively-charged carboxylate residues. The results suggest that the primary force for the successful deposition of PAMAM-COOH and PMA at pH 4.0 is hydrogen bonding between COOH residues on the surface of the dendrimer and PMA. The multilayer films are decomposed also at strongly acidic pH, suggesting an electrostatic force of attraction between the protonated tertiary amino groups in PAMAM-COOH and a small fraction of COO- residues in PMA contributes in part to the multilayer formation at pH 4.0. The PMA/PAMAM-COOH thin films can accommodate model dyes, Rose Bengal and 5,10,15,20-tetraphenyl-21H,23H-porphinetetrasulfonate, and the release can be controlled by changing pH.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalJournal of Colloid And Interface Science
Volume326
Issue number1
DOIs
Publication statusPublished - 2008 Oct 1

Keywords

  • Dendrimer
  • Hydrogen bonding
  • Layer-by-layer film
  • pH-controlled release

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Layer-by-layer assembled thin films composed of carboxyl-terminated poly(amidoamine) dendrimer as a pH-sensitive nano-device'. Together they form a unique fingerprint.

Cite this