Late pregnancy is vulnerable period for exposure to BPA

Naoko Ohtani, Koshi Suda, Erika Tsuji, Kentaro Tanemura, Hiroshi Yokota, Hiroki Inoue, Hidetomo Iwano

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)


    Bisphenol A (BPA) is among the better-known endocrine disruptors. BPA is used in various food-contacting materials and is easily eluted into food; as a result, we are exposed to BPA on a daily basis. In adults, BPA is metabolized and eliminated rapidly from the body. However, numerous reports suggest that fetuses and young children are susceptible to BPA. One of the concerning adverse effects of BPA is disruption of behavior, especially anxiety-like behavior. In order to study the mechanism of influences on offspring, it is important to clarify the most vulnerable gestation period. We hypothesized that offspring in late pregnancy would be more susceptible to BPA, because late pregnancy is a critical time for functional brain development. In this study, C57BL/6 mouse fetuses were exposed prenatally by oral dosing of pregnant dams, once daily from gestational day 5.5 to 12.5 (early pregnancy) or 11.5 to 18.5 (late pregnancy), with BPA (0 or 10 mg/kg body weight). Following birth and weaning, the resulting pups were tested using an elevated plus maze at postnatal week 10. The behavior of the offspring was altered by prenatal BPA exposure during late pregnancy but not during early pregnancy. These results indicated that offspring are more vulnerable to exposure to BPA in late pregnancy.

    Original languageEnglish
    Pages (from-to)536-543
    Number of pages8
    JournalJournal of Veterinary Medical Science
    Issue number3
    Publication statusPublished - 2018 Mar


    • Anxiety-like behavior
    • Bisphenol A
    • Endocrine disruptors
    • Late pregnancy

    ASJC Scopus subject areas

    • veterinary(all)


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