Landiolol suppression of electrical storm of torsades de pointes in patients with congenital long-QT syndrome type 2 and myocardial ischemia

Ryota Kitajima, Takeshi Aiba, Tsukasa Kamakura, Kohei Ishibashi, Mitsuru Wada, Yuko Inoue, Koji Miyamoto, Hideo Okamura, Takashi Noda, Satoshi Nagase, Yu Kataoka, Yasuhide Asaumi, Teruo Noguchi, Satoshi Yasuda, Kengo Kusano

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A 76-year-old man who had been diagnosed with long-QT syndrome type 2 had frequent syncopal attacks. The electrocardiogram was monitored, and frequent torsades de pointes (TdP) was detected despite administration of conventional medications: oral propranolol, verapamil, intravenous magnesium sulfate, verapamil, and lidocaine. In contrast, 2 μg/kg/min landiolol could completely suppress TdP. Subsequently, an implantable cardioverter defibrillator was placed, and he was diagnosed with silent myocardial ischemia using myocardial perfusion scintigraphy and coronary angiography. This is the first case report wherein landiolol effectively suppressed TdP due to long-QT syndrome with silent myocardial ischemia.

Original languageEnglish
Pages (from-to)501-504
Number of pages4
Journaljournal of arrhythmia
Volume33
Issue number5
DOIs
Publication statusPublished - 2017 Oct
Externally publishedYes

Keywords

  • Landiolol
  • Long-QT syndrome
  • Torsade de pointes
  • β-blocker

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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