Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia

Martin James Lear, Oliver Simon, Timothy L. Foley, Michael D. Burkart, Thomas J. Baiga, Joseph P. Noel, Antonio G. DiPasquale, Arnold L. Rheingold, James J. La Clair

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14 Citations (Scopus)

Abstract

(±)-Laetirobin (1) was isolated as a cytostatic lead from Laetiporus sulphureus growing parasitically on the black locust tree, Robinia pseudoacacia, by virtue of a reverse-immunoaffinity system. Using an LC/MS procedure, milligram quantities of (±)-laetirobin (1) were obtained, and the structure of 1 was elucidated by X-ray crystallography and confirmed by NMR spectroscopy. Preliminary cellular studies indicated that (±)-laetirobin (1) rapidly enters in tumor cells, blocks cell division at a late stage of mitosis, and invokes apoptosis.

Original languageEnglish
Pages (from-to)1980-1987
Number of pages8
JournalJournal of Natural Products
Volume72
Issue number11
DOIs
Publication statusPublished - 2009 Nov 30

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Lear, M. J., Simon, O., Foley, T. L., Burkart, M. D., Baiga, T. J., Noel, J. P., DiPasquale, A. G., Rheingold, A. L., & La Clair, J. J. (2009). Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. Journal of Natural Products, 72(11), 1980-1987. https://doi.org/10.1021/np9002838