Lack of effect of apolipoprotein E E4 allele on neuropsychiatric manifestations in Alzheimer's disease

Nobutsugu Hirono, Etsuro Mori, Minoru Yasuda, Toru Imamura, Tatsuo Shimomura, Mamoru Hashimoto, Satoshi Tanimukai, Hiroaki Kazui, Hikari Yamashita

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

The association between the apolipoprotein E epsilon 4 (APOE E4) allele and a wide spectrum of behavioral symptoms of Alzheimer's disease (AD) was investigated. Neither the severity nor the presence of any behavioural changes was associated with the number of APOE E4 alleles, even after controlling for the effects of age at onset, sex, education level, duration of illness, and severity of the dementia. The findings do not support the hypothesis that neuropsychiatric manifestations of AD are different in patients with the APOE E4 allele.

Original languageEnglish
Pages (from-to)66-70
Number of pages5
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume11
Issue number1
DOIs
Publication statusPublished - 1999 Jan 1

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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