Lack of association between TrkA single nucleotide polymorphisms and sporadic Alzheimer's disease in a Japanese population

Yuji Sakasegawa, Hitaru Kishida, Michiko Sakurai, Takashi Asada, Toru Kinoshita, Yuichi Goto, Hideo Kimura, Yoshiyuki Kuroiwa, Naomi S. Hachiya, Kiyotoshi Kaneko

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Abstract

Nerve growth factor and its receptor with tyrosine kinase activity (TrkA) have been implicated in the development of Alzheimer's disease (AD). Entire coding regions of TrkA gene harboring exons 1 through 17 were sequenced in 114 patients with sporadic AD and 112 control subjects in a Japanese population, and six known and two novel single nucleotide polymorphisms were identified, but no mutation associated with sporadic AD was identified. Concurrently, case-control analysis of TrkA gene A1674G polymorphism in 534 patients with sporadic AD and 454 control subjects has revealed no significant differences in TrkA genotype or allele frequencies even after stratification for Apolipoprotein E ε4 carrier statuses. Thus, the TrkA genotype does not appear to influence the risk of developing sporadic AD in a Japanese population.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalNeuroscience Letters
Volume353
Issue number1
DOIs
Publication statusPublished - 2003 Dec 15

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Case-control study
  • Nerve growth factor
  • Single nucleotide polymorphisms
  • Tyrosine kinase A

ASJC Scopus subject areas

  • Neuroscience(all)

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    Sakasegawa, Y., Kishida, H., Sakurai, M., Asada, T., Kinoshita, T., Goto, Y., Kimura, H., Kuroiwa, Y., Hachiya, N. S., & Kaneko, K. (2003). Lack of association between TrkA single nucleotide polymorphisms and sporadic Alzheimer's disease in a Japanese population. Neuroscience Letters, 353(1), 49-52. https://doi.org/10.1016/j.neulet.2003.09.016