Labdane-type diterpenes and flavones from Dodonaea viscosa

Hippolyte Kamdem Wabo; Philippe Chabert; Pierre Tane; Olivier Noté; Michel Feussi Tala; Jean Peluso; Christian Muller; Haruhisa Kikuchi; Yoshiteru Oshima; Annelise Lobstein

doi:10.1016/j.fitote.2012.03.014

Labdane-type diterpenes and flavones from Dodonaea viscosa

Hippolyte Kamdem Wabo, Philippe Chabert, Pierre Tane, Olivier Noté, Michel Feussi Tala, Jean Peluso, Christian Muller, Haruhisa Kikuchi, Yoshiteru Oshima, Annelise Lobstein

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

A new labdane diterpenoid, 2,18-dihydroxylabda-7,13(E)-dien-15-oic acid (1), together with two known labdane diterpenes (3, 4), a new flavone, 5,7-dihydroxy-3,6,4′-trimethoxy-3′-(4-hydroxy-3-methyl-but-2-enyl) flavone (2) with three known flavones (5-7) were isolated from the aerial parts of Dodonaea viscosa. Their structures were determined by extensive analysis of spectroscopic data (1D and 2D NMR, MS) and by comparison with literature data. The anti-inflammatory activity of five compounds (1-5) was evaluated with a flow cytometry TNF-α secretion assay on human THP-1 cell line.

Original language	English
Pages (from-to)	859-863
Number of pages	5
Journal	Fitoterapia
Volume	83
Issue number	5
DOIs	https://doi.org/10.1016/j.fitote.2012.03.014
Publication status	Published - 2012 Jul 1

Keywords

Anti-inflammatory activity
Dodonaea viscosa
Flavones
Labdane diterpenes
Sapindaceae

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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Labdane-type diterpenes and flavones from Dodonaea viscosa. / Wabo, Hippolyte Kamdem; Chabert, Philippe; Tane, Pierre; Noté, Olivier; Tala, Michel Feussi; Peluso, Jean; Muller, Christian; Kikuchi, Haruhisa; Oshima, Yoshiteru; Lobstein, Annelise.

In: Fitoterapia, Vol. 83, No. 5, 01.07.2012, p. 859-863.

Research output: Contribution to journal › Article › peer-review

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abstract = "A new labdane diterpenoid, 2,18-dihydroxylabda-7,13(E)-dien-15-oic acid (1), together with two known labdane diterpenes (3, 4), a new flavone, 5,7-dihydroxy-3,6,4′-trimethoxy-3′-(4-hydroxy-3-methyl-but-2-enyl) flavone (2) with three known flavones (5-7) were isolated from the aerial parts of Dodonaea viscosa. Their structures were determined by extensive analysis of spectroscopic data (1D and 2D NMR, MS) and by comparison with literature data. The anti-inflammatory activity of five compounds (1-5) was evaluated with a flow cytometry TNF-α secretion assay on human THP-1 cell line.",

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AU - Tala, Michel Feussi

AU - Peluso, Jean

AU - Muller, Christian

AU - Kikuchi, Haruhisa

AU - Oshima, Yoshiteru

AU - Lobstein, Annelise

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