Labdane-type diterpenes and flavones from Dodonaea viscosa

Hippolyte Kamdem Wabo, Philippe Chabert, Pierre Tane, Olivier Noté, Michel Feussi Tala, Jean Peluso, Christian Muller, Haruhisa Kikuchi, Yoshiteru Oshima, Annelise Lobstein

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

A new labdane diterpenoid, 2,18-dihydroxylabda-7,13(E)-dien-15-oic acid (1), together with two known labdane diterpenes (3, 4), a new flavone, 5,7-dihydroxy-3,6,4′-trimethoxy-3′-(4-hydroxy-3-methyl-but-2-enyl) flavone (2) with three known flavones (5-7) were isolated from the aerial parts of Dodonaea viscosa. Their structures were determined by extensive analysis of spectroscopic data (1D and 2D NMR, MS) and by comparison with literature data. The anti-inflammatory activity of five compounds (1-5) was evaluated with a flow cytometry TNF-α secretion assay on human THP-1 cell line.

Original languageEnglish
Pages (from-to)859-863
Number of pages5
JournalFitoterapia
Volume83
Issue number5
DOIs
Publication statusPublished - 2012 Jul

Keywords

  • Anti-inflammatory activity
  • Dodonaea viscosa
  • Flavones
  • Labdane diterpenes
  • Sapindaceae

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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