Kv1.2-immunoreactive primary sensory neurons in the rat trigeminal ganglion

Hiroyuki Ichikawa, Tomosada Sugimoto

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Immunohistochemistry for Kv1.2, a subunit of voltage-gated K+ channels, was performed on the trigeminal ganglion (TG). Immunoreactivity (ir) was detected in half (48%) the TG neurons. These neurons were mostly medium-sized to large (range 137.6-2664.8 μm2, mean±S.D. 892.6±413.3 μm2). A double immunofluorescence method also revealed co-expression of Kv1.2 and parvalbumin. Half (54%) the Kv1.2-immunoreactive (ir) neurons exhibited parvalbumin-ir, and parvalbumin-ir neurons mostly showed Kv1.2-ir (95%). Kv1.2-ir neurons which co-expressed CGRP-ir were rare in this ganglion. Some 40% of TG neurons retrogradely labeled from the facial skin exhibited Kv1.2-ir, whereas ir was detected in 16% of those labeled from the tooth pulp. The present study indicates that Kv1.2-ir TG neurons include low-threshold mechanoreceptors and nociceptors which innervate the facial skin and tooth pulp, respectively.

Original languageEnglish
Pages (from-to)222-227
Number of pages6
JournalBrain research
Volume974
Issue number1-2
DOIs
Publication statusPublished - 2003 Jun 6
Externally publishedYes

Keywords

  • Calcitonin gene-related peptide
  • Facial skin
  • Immunohistochemistry
  • Kv1.2
  • Parvalbumin
  • Tooth pulp
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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