Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells

Ryo Nakano; Tsutomu Takahashi; Akira Naganuma; Gi Wook Hwang

doi:10.2131/jts.38.821

Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells

Ryo Nakano, Tsutomu Takahashi, Akira Naganuma, Gi Wook Hwang

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

HEK293 cells transfected with a double-stranded siRNA to suppress expression of the homeobox gene HOXB13 were highly resistant to oxidative stress-inducing agents, such as hydrogen peroxide, A-ethylmaleimide (NEM), and paraquat. This finding suggests that HOXB13 might enhance cell injury caused by oxidative stress.

Original language	English
Pages (from-to)	821-822
Number of pages	2
Journal	Journal of Toxicological Sciences
Volume	38
Issue number	6
DOIs	https://doi.org/10.2131/jts.38.821
Publication status	Published - 2013

Keywords

Cytotoxicity
HOXB13
Homeobox gene
Oxidative stress

ASJC Scopus subject areas

Toxicology

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10.2131/jts.38.821

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title = "Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells",

abstract = "HEK293 cells transfected with a double-stranded siRNA to suppress expression of the homeobox gene HOXB13 were highly resistant to oxidative stress-inducing agents, such as hydrogen peroxide, A-ethylmaleimide (NEM), and paraquat. This finding suggests that HOXB13 might enhance cell injury caused by oxidative stress.",

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AU - Nakano, Ryo

AU - Takahashi, Tsutomu

AU - Naganuma, Akira

AU - Hwang, Gi Wook

PY - 2013

Y1 - 2013

N2 - HEK293 cells transfected with a double-stranded siRNA to suppress expression of the homeobox gene HOXB13 were highly resistant to oxidative stress-inducing agents, such as hydrogen peroxide, A-ethylmaleimide (NEM), and paraquat. This finding suggests that HOXB13 might enhance cell injury caused by oxidative stress.

AB - HEK293 cells transfected with a double-stranded siRNA to suppress expression of the homeobox gene HOXB13 were highly resistant to oxidative stress-inducing agents, such as hydrogen peroxide, A-ethylmaleimide (NEM), and paraquat. This finding suggests that HOXB13 might enhance cell injury caused by oxidative stress.

KW - Cytotoxicity

KW - HOXB13

KW - Homeobox gene

KW - Oxidative stress

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ER -

Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells

Abstract

Keywords

ASJC Scopus subject areas

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