Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells

Ryo Nakano, Tsutomu Takahashi, Akira Naganuma, Gi Wook Hwang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

HEK293 cells transfected with a double-stranded siRNA to suppress expression of the homeobox gene HOXB13 were highly resistant to oxidative stress-inducing agents, such as hydrogen peroxide, A-ethylmaleimide (NEM), and paraquat. This finding suggests that HOXB13 might enhance cell injury caused by oxidative stress.

Original languageEnglish
Pages (from-to)821-822
Number of pages2
JournalJournal of Toxicological Sciences
Volume38
Issue number6
DOIs
Publication statusPublished - 2013 Nov 18

Keywords

  • Cytotoxicity
  • HOXB13
  • Homeobox gene
  • Oxidative stress

ASJC Scopus subject areas

  • Toxicology

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